Motesanib
Motesanib Basic information
- Product Name:
- Motesanib
- Synonyms:
-
- CS-1108
- AMG 706; AMG-706
- N-(3,3-diMethylindolin-6-yl){2-[(4-pyridylMethyl)-aMino](3-pyridyl)}-carboxaMide
- 3-PyridinecarboxaMide, N-(2,3-dihydro-3,3-diMethyl-1H-indol-6-yl)-2-[(4-pyridinylMethyl)aMino]-
- Motesanib Base
- AMG-706(Motesanib)
- Motesanib (AMG-706) Base)
- motesanib
- CAS:
- 453562-69-1
- MF:
- C22H23N5O
- MW:
- 373.45
- Product Categories:
-
- API
- Inhibitors
- Antineoplastic
- Mol File:
- 453562-69-1.mol
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Motesanib Chemical Properties
- Melting point:
- 147-150°C
- Boiling point:
- 517.3±50.0 °C(Predicted)
- Density
- 1.251
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- White powder solid.
- pka
- 11.75±0.40(Predicted)
- color
- Pale Yellow
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Motesanib Usage And Synthesis
Chemical Properties
Pale Yellow Solid
Uses
Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.
Uses
Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.
Definition
ChEBI: Motesanib is a pyridinecarboxamide.
target
VEGFR1
MotesanibSupplier
Tianjin Kailiqi Biotechnology Co., Ltd. Gold
- Tel
- 15076683720
- klq@cw-bio.com
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
ZHIWE CHEMTECH CO LTD
- Tel
- 021-20221225 13917446399
- sales@zhiwe.net
Chembest Research Laboratories Limited
- Tel
- +86-21-20908456
- sales@BioChemBest.com
LGM Pharma
- Tel
- 1-(800)-881-8210
- inquiries@lgmpharma.com
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Motesanib(453562-69-1)Related Product Information
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- Imiquimod
- Dacthal
- Dimethyl fumarate
- N,N-Dimethylformamide
- Dimethyl carbonate
- Dimethyl sulfoxide
- Dimethyl sulfate
- Dimethyl phthalate
- Dimethyl ether
- ETHANE
- 2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
- N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE
- Compound 23
- ERK Inhibitor
- 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
- Motesanib