Basic information Safety Supplier Related

Compound 23

Basic information Safety Supplier Related

Compound 23 Basic information

Product Name:
Compound 23
Synonyms:
  • Compound 23
  • mTOR Inhibitor, WYE-23
  • methyl 4-(6-(4-[(cyclopropylcarbamoyl)amino]phenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
  • WYE-23
  • 1-Piperidinecarboxylic acid, 4-[6-[4-[[(cyclopropylamino)carbonyl]amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, methyl ester
  • 4-[6-[4-[[(cyclopropylamino)carbonyl]amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylicacid,methylester
CAS:
1062169-46-3
MF:
C26H32N8O4
MW:
520.58
Mol File:
1062169-46-3.mol
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Compound 23 Chemical Properties

Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
White powder solid.
pka
13.53±0.20(Predicted)
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Compound 23 Usage And Synthesis

Uses

mTOR inhibitor WYE-23 is a mTOR inhibitor, and IC50 is 0.45 nM. It is selective to PI3Kα and IC50 is 661 nM. mTOR inhibitor WYE-23 has antitumor activity[1][2].

References

[1] Nikola P. Pavletich et al. mTOR CRYSTALS AND MODULATORS. WO2014176281A1.2014-10-30.
[2] Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. DOI:10.1021/jm900851f

Compound 23Supplier

BOC Sciences
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16314854226
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info@bocsci.com
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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info@efebio.com
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
Email
sales@chemegen.com
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
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Compound 23(1062169-46-3)Related Product Information