FOSALVUDINE TIDOXIL
FOSALVUDINE TIDOXIL Basic information
- Product Name:
- FOSALVUDINE TIDOXIL
- Synonyms:
-
- FOSALVUDINE TIDOXIL
- JHXLLEDIXXOJQD-WELGVCPWSA-N
- HDP 99.0003
- HDP 990003
- HDP99.0003
- HDP-99.0003
- HDP990003
- HDP-990003
- CAS:
- 763903-67-9
- MF:
- C35H64FN2O8PS
- MW:
- 722.93
- Mol File:
- 763903-67-9.mol
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FOSALVUDINE TIDOXIL Chemical Properties
- Density
- 1.14±0.1 g/cm3(Predicted)
- pka
- 1.36±0.50(Predicted)
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FOSALVUDINE TIDOXIL Usage And Synthesis
Uses
Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection[1].
in vivo
Fosalvudine tidoxil (15-100 mg/kg/day; oral; 8 weeks) induces significant mitochondrial hepatotoxicity in rats[1].
| Animal Model: | Sprague-Dawley rats[1] |
| Dosage: | 15, 40, or 100 mg/kg/day |
| Administration: | Oral gavage, 8 weeks |
| Result: | Induced significant mtDNA depletion. At doses of 15, 40, and 100 mg/kg, the mean hepatic mtDNA values were 62, 64, and 47% of control values, respectively. |
References
[1] Venhoff AC, et al. Mitochondrial DNA depletion in rat liver induced by fosalvudine tidoxil, a novel nucleoside reverse transcriptase inhibitor prodrug. Antimicrob Agents Chemother. 2009 Jul;53(7):2748-51. DOI:10.1128/AAC.00364-09
FOSALVUDINE TIDOXILSupplier
LGM Pharma
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- 1-(800)-881-8210
- inquiries@lgmpharma.com
TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com
TargetMol Chemicals Inc.
- Tel
- 15002134094
- marketing@targetmol.cn
TargetMol Chemicals Inc.
- Tel
- +17819995354
- marketing@targetmol.com