7-Chloro-1H-indole-3-carbaldehyde Chemical Properties

Melting point:

181-182 °C(Solv: ethyl acetate (141-78-6))

Boiling point:

373.4±22.0 °C(Predicted)

Density 

1.431±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

13.92±0.30(Predicted)

Appearance

White to yellow Solid

Safety Information

HS Code 

2933998090

7-Chloro-1H-indole-3-carbaldehyde Usage And Synthesis

Synthesis

The general procedure for the synthesis of 7-chloro-1H-indole-3-aldehyde from 7-chloro-1H-indole was as follows: phosphoryl chloride (0.66 mL, 7 mmol) was slowly added dropwise to anhydrous DMF (5 mL) at 0 °C and under argon protection. Subsequently, a solution of 7-chloro-1H-indole (1 g, 6.6 mmol) dissolved in anhydrous DMF (15 mL) was added dropwise to the above mixture at room temperature. The reaction mixture was stirred continuously for 2 hours at room temperature. After completion of the reaction, the mixture was slowly poured into a mixture of ice water and saturated NaHCO3 solution and extracted with ethyl acetate. The organic phases were combined, washed with saturated NaCl solution (10 mL x 3), dried over anhydrous MgSO4, filtered and concentrated to give 990 mg of the target product 7-chloro-1H-indole-3-aldehyde as a yellow-orange solid in 83% yield.

References

[1] Patent: US2005/119260, 2005, A1. Location in patent: Page/Page column 36

7-Chloro-1H-indole-3-carbaldehyde(1008-07-7)Related Product Information

• 7-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID
• 3-HYDROXY-7-CHLORO 1H-INDAZOLE
• METHYL 7-CHLORO-1H-INDAZOLE-3-CARBOXYLATE
• 7-Chloroindole
• 7-CHLORO-1H-INDAZOL-3-YLAMINE
• 7-CHLORO-1H-PYRROLO[3,2-B]PYRIDINE
• 7-Chloro-3H-[1,2,3]triazolo[4,5-b]pyridine
• 7-chloro-1H-pyrrolo[3,2-b]pyridin-3-aMine
• 7-Chloro-1H-imidazo[4,5-c]pyridine
• 7-CHLORO-1H-INDOL-3-METHYLAMINE
• 7-CHLORO-1H-INDOLE-3-CARBOXYLIC ACID
• 1H-Indole-3-carboxylic acid, 2-aminomethyl-1-ethyl-4,5,6,7-tetrachloro -, ethyl ester
• 7-CHLORO-ALPHA-OXO-1H-INDOLE-3-ACETYL CHLORIDE
• 8-chloro-2,2-dimethyl-2,3,4,9-tetrahydro-1H-carbazol-4-one
• 7-CHLORO-3-FORMYLINDOLE