6-DIAZO-5-OXO-D-NORLEUCINE
6-DIAZO-5-OXO-D-NORLEUCINE Basic information
- Product Name:
- 6-DIAZO-5-OXO-D-NORLEUCINE
- Synonyms:
-
- 6-DIAZO-5-OXO-D-2-AMINOHEXANOIC ACID
- 6-DIAZO-5-OXO-D-NORLEUCINE
- D-DON
- H-D-NLE(6-DIAZO-5-OXO)-OH
- H-6-DIAZO-5-OXO-D-NLE-OH
- H-6-DIAZO-5-OXO-D-NORLEUCINE
- D-DON, 6-Diazo-5-oxo-D-2-aMinohexanoic acid, H-D-Glu(diazoMethylketone)-OH
- (R)-2-Amino-6-diazo-5-oxocaproic acid, (R)-6-Diazo-5-oxo-L-norleucine
- CAS:
- 71629-86-2
- MF:
- C6H9N3O3
- MW:
- 171.15
- Product Categories:
-
- A - H
- Amino Acids
- Modified Amino Acids
- Mol File:
- 71629-86-2.mol
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6-DIAZO-5-OXO-D-NORLEUCINE Chemical Properties
- storage temp.
- −20°C
- form
- powder
- color
- faint yellow to yellow-brown
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MSDS
- Language:English Provider:SigmaAldrich
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6-DIAZO-5-OXO-D-NORLEUCINE Usage And Synthesis
Uses
6-Diazo-5-oxo-D-norleucine, a D-Glutamine (HY-100587) analog, is a γ-glutamyl transferase inhibitor[1].
Biological Activity
6-Diazo-5-oxo-D-norleucine is the enantiomer of α amino acid 6-diazo-5-oxo-L-norleucine (DON).
References
[1] Inoue M, et al. Inactivation of renal gamma-glutamyl transferase by 6-diazo-5-oxo-L-norleucylglycine, an inactive precursor of affinity-labeling reagent. Proc Natl Acad Sci U S A. 1981 Jan;78(1):46-9. DOI:10.1073/pnas.78.1.46
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