Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Specialty drugs >  Antidote >  Triethylenetetramine

Triethylenetetramine

Basic information Safety Supplier Related

Triethylenetetramine Basic information

Product Name:
Triethylenetetramine
Synonyms:
  • N,N'-DI(2-AMINOETHYL)ETHYLENEDIAMINE
  • N,N'-BIS(2-AMINOETHYL)ETHYLENEDIAMINE
  • Ethylenediamine, N,N'-bis(2-aminoethyl)-
  • hy951
  • n,n’-bis(2-aminoethyl)-2-ethanediamine
  • N,N’-bis-(2-amino-ethyl)-ethane-1,2-diamine
  • n,n’-bis(2-aminoethyl)-ethylenediamin
  • N,N'-Bis(2-aminoethyl)-1,2-diaminoethane
CAS:
112-24-3
MF:
C6H18N4
MW:
146.23
EINECS:
203-950-6
Product Categories:
  • Nitrogen Compounds
  • Organic Building Blocks
  • Polyamines
Mol File:
112-24-3.mol
More
Less

Triethylenetetramine Chemical Properties

Melting point:
12 °C(lit.)
Boiling point:
266-267 °C(lit.)
Density 
0.982 g/mL at 25 °C(lit.)
vapor density 
~5 (vs air)
vapor pressure 
<0.01 mm Hg ( 20 °C)
refractive index 
n20/D 1.496(lit.)
Flash point:
290 °F
storage temp. 
Store below +30°C.
solubility 
alcohol: soluble
pka
pK1:3.32(+4);pK2:6.67(+3);pK3:9.20(+2);pK4:9.92(+1) (20°C)
PH
10-11 (10g/l, H2O, 20℃)
explosive limit
0.7-7.2%(V)
Water Solubility 
SOLUBLE
FreezingPoint 
12℃
Sensitive 
Moisture Sensitive
Merck 
14,9663
BRN 
605448
Stability:
Syable. Incompatible with strong oxidizing agents, strong acids.
CAS DataBase Reference
112-24-3(CAS DataBase Reference)
NIST Chemistry Reference
Triethylenetetramine(112-24-3)
EPA Substance Registry System
1,2-Ethanediamine, N,N'-bis(2-aminoethyl)- (112-24-3)
More
Less

Safety Information

Hazard Codes 
C
Risk Statements 
21-34-43-52/53
Safety Statements 
26-36/37/39-45-61
RIDADR 
UN 2259 8/PG 2
WGK Germany 
2
RTECS 
YE6650000
Autoignition Temperature
335 °C
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29212900
Hazardous Substances Data
112-24-3(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 2.5 g/kg (Spitz)

MSDS

More
Less

Triethylenetetramine Usage And Synthesis

Uses

Triethylenetetramine is a selective CuII-chelator; crosslinking agent. Triethylenetetramine is undergoing trials for the treatment of heart failure in patients with diabetes.

brand name

Syprine (Merck).

General Description

A yellowish liquid. Less dense than water. Combustible, though may be difficult to ignite. Corrosive to metals and tissue. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used in detergents and in the synthesis of dyes, pharmaceuticals and other chemicals.

Reactivity Profile

Triethylenetetramine is a strong base; reacts violently with strong oxidants; attacks aluminum, zinc, copper and its alloys. Handling Chemicals Safely 198. p. 934).

Health Hazard

Vapors from hot liquid can irritate eyes and upper respiratory system. Liquid burns eyes and skin. May cause sensitization of skin.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Contact allergens

Triethylenetetramine is used as an amine hardener in epoxy resins of the bisphenol A type. Cross-sensitivity is possible with diethylenetriamine and diethylenediamine.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and skin contact. An experimental teratogen. Experimental reproductive effects. Mutation data reported. A corrosive irritant to skin, eyes, and mucous membranes. Causes skin sensitization. Combustible when exposed to heat or flame. Ignites on contact with cellulose nitrate of high surface area. Can react with oxidizing materials. To fight fire, use CO2, dry chemical, alcohol foam. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Dry the amine with sodium, then distil it under a vacuum. Further purification has been via the nitrate or the chloride salts. For example, Jonassen and Strickland [J Am Chem Soc 80 312 1958] separated TRIEN from admixture with TREN (38%) by solution in EtOH, cooling to approximately 5o in an ice-bath and adding conc HCl dropwise from a burette, keeping the temperature below 10o, until all of the white crystalline precipitate of TREN.HCl (see p 191) had formed and was removed. Further addition of HCl then precipitated thick, creamy white TRIEN.HCl (see below) which was crystallised several times from hot water by adding an excess of cold EtOH. The crystals were finally washed with Me2CO, then Et2O and dried in a vacuum desiccator. [Beilstein 4 H 255, 4 II 695, 4 III 542, 4 IV 1242.]

TriethylenetetramineSupplier

Jinan Century Tongda Chemical Co., Ltd. Gold
Tel
13370556116 0531-58051019
Email
3350933950@qq.com
J & K SCIENTIFIC LTD.
Tel
400-666-7788 +86-10-82848833
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
+86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
Email
sh@meryer.com
Alfa Aesar
Tel
400-610-6006; 021-67582000
Email
saleschina@alfa-asia.com
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Email
Sales-CN@TCIchemicals.com