ETHYL 4-(TRIFLUOROMETHYL)PHENYL ACETATE Chemical Properties

Melting point:

34-35 °C

Boiling point:

104-105 °C(Press: 7 Torr)

Density 

1.207

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

Solid

color 

Colorless

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

2916340000

ETHYL 4-(TRIFLUOROMETHYL)PHENYL ACETATE Usage And Synthesis

Synthesis

General procedure: Under standard Schlenk operating conditions, the reaction system is first evacuated and backfilled three times with dry pure nitrogen. To a pre-dried Schlenk tube fitted with a magnetic stirring bar, palladium catalyst (see Tables 1 to 4 for specific types and amounts), ligand (see Tables 1 to 4), N,N-dimethylpyridin-4-amine (DMAP, see Tables 1 to 4), and monoethyl malonate potassium salt (see Tables 1 to 4) are added sequentially. Subsequently, the reaction tube was evacuated and backfilled with argon, and this process was repeated three times. Under argon protection, p-bromobenzotrifluoride (see Tables 1 through 4) and an appropriate amount of solvent (see Tables 1 through 4) were added via syringe. The reaction tube was sealed and stirred for 10 minutes at room temperature. Afterwards, the reaction tube is connected to a Schlenk line pre-filled with argon and placed in an oil bath preheated to 140-150°C and the reaction is stirred for 20-25 hours. After completion of the reaction, the reaction was cooled to room temperature, the reaction mixture was diluted with ether and the yield of ethyl 4-(trifluoromethyl)phenylacetate was determined by gas chromatography using 1,3-dimethoxybenzene as an internal standard.

References

[1] Tetrahedron, 2012, vol. 68, # 9, p. 2113 - 2120

ETHYL 4-(TRIFLUOROMETHYL)PHENYL ACETATE(721-63-1)Related Product Information

• 4-(Trifluoromethyl)phenyl acetate
• 4-(Trifluoromethyl)phenylacetic acid
• Ethyl phenylacetate
• RARECHEM AL BI 1336
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• RARECHEM AL BW 0991
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• ETHYL OXO-(4-TRIFLUOROMETHYLPHENYL)ACETATE
• ETHYL ALPHA-CYANO-2-NITRO-4-(TRIFLUOROMETHYL)PHENYLACETATE
• 3,3,3-TRIFLUORO-2-HYDROXY-2-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER
• ETHYL 3,5-BIS(TRIFLUOROMETHYL)PHENYL ACETATE