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Sodium dihydrogen phosphate dihydrate

Basic information Description References Safety Supplier Related

Sodium dihydrogen phosphate dihydrate Basic information

Product Name:
Sodium dihydrogen phosphate dihydrate
Synonyms:
  • monosodiumdihydrogenphosphatedihydrate
  • Phosphoricacid,monosodiumsalt,dihydrate
  • Phosphoricacidmonosodiumsalt,dihydrate
  • Sodiumdihydrogenphosphate,di
  • SodiumDihydrogenPhosphateDihydrateBp
  • SodiumDihydrogenPhosphateDihydrateUsp
  • MonosodiumPhosphateFoodGradeHydrous
  • SodiumDihydrogenPhosphateDihydrateIp
CAS:
13472-35-0
MF:
H6NaO6P
MW:
156.01
EINECS:
603-853-2
Product Categories:
  • Food Additives,Industrial agent,Medical additives
Mol File:
13472-35-0.mol
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Sodium dihydrogen phosphate dihydrate Chemical Properties

Melting point:
60 °C
Density 
1,915 g/cm3
storage temp. 
Store at +5°C to +30°C.
solubility 
H2O: 1 M at 20 °C, clear, colorless
form 
Solid
color 
White
Odor
Odorless
PH
4.0-4.5 (25℃, 50mg/mL in H2O)
PH Range
4.2 - 4.5
Water Solubility 
SOLUBLE
λmax
λ: 260 nm Amax: 0.085
λ: 280 nm Amax: 0.070
Sensitive 
Hygroscopic
Merck 
14,8660
Stability:
Stable.
InChIKey
VBJGJHBYWREJQD-UHFFFAOYSA-M
CAS DataBase Reference
13472-35-0(CAS DataBase Reference)
EPA Substance Registry System
Phosphoric acid, monosodium salt (13472-35-0)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36-36/37/38
Safety Statements 
39-26-24/25-36
WGK Germany 
1
RTECS 
WA1900500
TSCA 
Yes
HS Code 
2835 22 00
Toxicity
LD50 orally in Rabbit: 8290 mg/kg LD50 dermal Rabbit > 7940 mg/kg

MSDS

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Sodium dihydrogen phosphate dihydrate Usage And Synthesis

Description

Sodium Dihydrogen Phosphate occurs as two forms: the crystal form (dihydrate) called Sodium Dihydrogen Phosphate (crystal) and anhydrous form called Sodium Dihydrogen Phosphate (anhydrous)
It is used as an acidity regulator and sequestrant in foods. It is used as a pH buffer (baking powders, fleet enema solution, electroplating baths, and acid cleaners), emulsifier, laboratory reagent, metal phosphating reagent, and textile dyeing/printing auxiliary. It is also used to treat boiled water and waste waster and to remove halogen from waste gases. Furthermore, it is used as a cattle feed supplement, as nutritional supplement in food, in dentrifice formulations, in vitreous enamel frits, for the synthesis of pharmaceuticals, and as a phosphate source for micro-organisms in effluent treatment.

References

[1] http://sydney.edu.au
[2] https://hazmap.nlm.nih.gov
[3] https://www.chemsupply.com.au

Chemical Properties

white crystalline solid

Chemical Properties

The USP 32 states that monobasic sodium phosphate contains one or two molecules of water of hydration or is anhydrous.
The hydrated forms of monobasic sodium phosphate occur as odorless, colorless or white, slightly deliquescent crystals. The anhydrous form occurs as a white crystalline powder or granules.

Uses

Sodium dihydrogen phosphate dihydrate acts as buffering capacity reagent in molecular biology, biochemistry and chromatography. It is used in the preparation of biological buffers. It is also used in the purification of antibodies, as a laxative and, in combination with other sodium phosphates.
Sodium phosphate monobasic dihydrate is a reagent with very high buffering capacity widely used in molecular biology, biochemistry and chromatography. Sodium phosphate dibasic is highly hygroscopic and water soluble.
Recommended chemicals for the preparation of phosphate buffers are sodium dihydrogen phosphate dihydrate,NaH2PO4.2H2O(mol. wt.156.0),disodium hydrogen phosphate dihydrate,Na2HPO4.2H2O (mol. wt.178.0), and sodium hydroxide pellets.

Uses

Sodium dihydrogen phosphate dihydrate acts as buffering capacity reagent in molecular biology, biochemistry and chromatography. It is used in the preparation of biological buffers. It is also used in the purification of antibodies, as a laxative and, in combination with other sodium phosphates

Production Methods

Monobasic sodium phosphate is prepared by adding phosphoric acid to a hot, concentrated solution of disodium phosphate until the liquid ceases to form a precipitate with barium chloride. This solution is then concentrated and the monobasic sodium phosphate is crystallized.

Pharmaceutical Applications

Monobasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, monobasic sodium phosphate is used as a mild saline laxative and in the treatment of hypophosphatemia.
Monobasic sodium phosphate is also used in food products, for example, in baking powders, and as a dry acidulant and sequestrant.

Safety

Monobasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia virtually unknown except in certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces. Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally (2–4 g of monobasic sodium phosphate in an aqueous solution is used as a laxative). Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of monobasic sodium phosphate as an excipient in oral formulations. However, the level of monobasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.
LD50 (rat, IM): 0.25 g/kg(10)
LD50 (rat, oral): 8.29 g/kg

storage

Monobasic sodium phosphate is chemically stable, although it is slightly deliquescent. On heating at 100°C, the dihydrate loses all of its water of crystallization. On further heating, it melts with decomposition at 205℃, forming sodium hydrogen pyrophosphate, Na2H2P2O7. At 250℃ it leaves a final residue of sodium metaphosphate, NaPO3.
Aqueous solutions are stable and may be sterilized by autoclaving.
Monobasic sodium phosphate should be stored in an airtight container in a cool, dry place.

Incompatibilities

Monobasic sodium phosphate is an acid salt and is therefore generally incompatible with alkaline materials and carbonates; aqueous solutions of monobasic sodium phosphate are acidic and will cause carbonates to effervesce.
Monobasic sodium phosphate should not be administered concomitantly with aluminum, calcium, or magnesium salts since they bind phosphate and could impair its absorption from the gastrointestinal tract. Interaction between calcium and phosphate, leading to the formation of insoluble calcium phosphate precipitates, is possible in parenteral admixtures.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections; infusions; ophthalmic, oral, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Sodium dihydrogen phosphate dihydrate Preparation Products And Raw materials

Raw materials

Sodium dihydrogen phosphate dihydrateSupplier

Spectrum Chemical Manufacturing Corp. Gold
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021-67601398-809
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marketing_china@spectrumchemical.com;
Shanghai Aladdin Bio-Chem Technology Co.,LTD Gold
Tel
400-62063333-1
Email
market@aladdin-e.com
ShangHai Anpel Co, Ltd. Gold
Tel
021-54890099
Email
shanpel@anpel.com.cn
Xuzhou Sunyu Chemical Technology Co., Ltd. Gold
Tel
0516-82282337
Email
luqs@songyucn.com
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833
Email
jkinfo@jkchemical.com;market6@jkchemical.com