Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Specialty drugs >  Ophthalmic drugs >  Bromfenac Sodium

Bromfenac Sodium

Basic information Safety Supplier Related

Bromfenac Sodium Basic information

Product Name:
Bromfenac Sodium
Synonyms:
  • Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate
  • Benzeneacetic acid, 2-amino-3-(4-bromobenzoyl)-, monosodium salt, hydrate (2:3)
  • Bromfenac ophthalmic
  • Bromfenac ophthalmic solution
  • Duract
  • Sodium 2-amino-3-(4-bromobenzoyl) phenylacetate sesquihydrate
  • Unii-8ecv571Y37
  • Bromfenac monosodium salt sesquihydrate
CAS:
120638-55-3
MF:
C15H11BrNNaO3
MW:
356.15
EINECS:
695-342-6
Product Categories:
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API
Mol File:
120638-55-3.mol
More
Less

Bromfenac Sodium Chemical Properties

Melting point:
268-270°C (dec.)
storage temp. 
Refrigerator
solubility 
DMSO: ≥ 100 mg/mL (260.98 mM); Water: ≥ 100 mg/mL (260.98 mM)
form 
Solid
color 
Light yellow to yellow
More
Less

Bromfenac Sodium Usage And Synthesis

Description

Duract was launched in the US as a potent, orally-active, long lasting peripheral analgesic with antiinflammatory properties. It is structurally similar to ketoprofen and diclofenac and can be prepared in three steps from 2-amino-4’-bromophenone using Gassman’s oxindole synthesis. Duract’s biological effects are a result of its ability to reduce prostaglandin production through inhibition of cyclooxygenase. As a 4-bromo derivative of Amfenac, this modification increased the duration of analgesic activity and antiinflammatory potency. It was also free of any CNS, cardiovascular or autonomic effects. In comparison, 5 mg of Duract was equipotent to 650 mg of ASA and 25 mg was slightly more potent than 400 mg of Ibuprofen.

Chemical Properties

Yellow Solid

Originator

American Home Products (US)

Uses

Bromfenac (Xibrom, ISTA Pharmaceuticals, Irvine, USA; Bronuck, Senju Pharmaceutical, Osaka, Japan) is indicated for the treatment of postoperative inflammation and the reduction of ocular pain in patients after undergoing cataract extraction. For this task, one drop of Xibrom may be applied to the affected eye twice daily beginning 24 hours after cataract surgery and continuing for the first 2 weeks of the postoperative period. The clinical safety and efficacy of bromfenac have been extensively studied in diverse comparative investigations, including the treatment of external or anterior ocular inflammatory diseases, allergic conjunctivitis, scleritis, and postoperative inflammation.The results of two phase III multicenter, randomized double-masked placebo-controlled clinical trials showed that bromfenac ophthalmic solution 0.09% was effective in the rapid resolution of ocular pain after cataract surgery, and there was a statistically significant difference between the bromfenac and placebo groups demonstrated in these phase III clinical trials.

Uses

Bromfenac is a non-steroidal anti-inflammatory agent.

Definition

ChEBI: The sesquihydrate of the sodium salt of bromfenac. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction.

brand name

Xibrom (Ista).

Bromfenac SodiumSupplier

Shandong Kehui Pharmaceutical Co. LTD Gold
Tel
13276409687
Email
469553953@qq.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Email
chenyj@titansci.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com