ICRF-186 Chemical Properties

Boiling point:

531.5±50.0 °C(Predicted)

Density 

1.333±0.06 g/cm3(Predicted)

pka

11.00±0.20(Predicted)

InChI

InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m1/s1

InChIKey

BMKDZUISNHGIBY-SSDOTTSWSA-N

SMILES

[C@@H](N1CC(=O)NC(=O)C1)(C)CN1CC(=O)NC(=O)C1

ICRF-186 Usage And Synthesis

Uses

(R)-Levrazoxane ((R)-ICRF 186) is enzymatically hydrolysed to one-ring open intermediates by dihydropyrimidine amidohydrolase (DPHase), which is present in the liver and kidney. The radiosensitizing efficiency of (R)-Levrazoxane towards EMT6 mouse mammary tumour cells is greater than that of Dexrazoxane (HY-B0581). (R)-Levrazoxane is promising for research of liver and kidney related diseases[1].

References

[1] Hasinoff BB, et al. Metabolism of the cardioprotective agents dexrazoxane (ICRF-187) and levrazoxane (ICRF-186) by the isolated hepatocyte. Xenobiotica. 1994 Oct;24(10):977-87. DOI:10.3109/00498259409043295

ICRF-186(24613-06-7)Related Product Information

• Glycine, N-(2-amino-2-oxoethyl)-N-[2-(3,5-dioxo-1-piperazinyl)propyl]-
• Glycine, N-(2-amino-2-oxoethyl)-N-[(2R)-2-(3,5-dioxo-1-piperazinyl)propyl]-
• (S)-(+)-1,2-Diaminopropane-N,N,N',N'-tetraacetic acid
• 2,2',2'',2'''-[[(1S)-1-Methyl-1,2-ethanediyl]dinitrilo]tetrakisacetamide
• N-(2-Amino-2-oxoethyl)-N-[(2S)-2-(3,5-dioxo-1-piperazinyl)propyl]-glycine
• ICRF 198
• N-(2-Amino-2-oxoethyl)-N-[(1S)-2-(3,5-dioxo-1-piperazinyl)-1-methylethyl]-glycine
• Dexrazoxane