Dexrazoxane
Dexrazoxane Basic information
- Product Name:
- Dexrazoxane
- Synonyms:
-
- DEXRAZOXANE
- (s)-4,4'-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione
- 4’-(1-methyl-1,2-ethanediyl)bis-6-piperazinedion(+)-4
- 4’-propylenedi-6-piperazinedion(+)-4
- adr529
- cardioxane
- DEXTRAZOXANE
- DEXTRORAZOXANE
- CAS:
- 24584-09-6
- MF:
- C11H16N4O4
- MW:
- 268.27
- EINECS:
- 206-169-7
- Product Categories:
-
- API
- Chelating Agent
- 24584-09-6
- Mol File:
- 24584-09-6.mol
Dexrazoxane Chemical Properties
- Melting point:
- 194-196°C
- alpha
- D +11.35° (c = 5 in DMF)
- Boiling point:
- 531.5±50.0 °C(Predicted)
- Density
- 1.333±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- form
- powder
- pka
- 2.1(at 25℃)
- color
- white to off-white
- Merck
- 14,8123
- InChIKey
- BMKDZUISNHGIBY-ZETCQYMHSA-N
- CAS DataBase Reference
- 24584-09-6(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- RTECS
- TL6390000
- HS Code
- 2933.59.9500
- Hazardous Substances Data
- 24584-09-6(Hazardous Substances Data)
Dexrazoxane Usage And Synthesis
Description
Dexrazoxane is the dextro-isomer of razoxane approved as a protectant against the cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the anticancer effect of doxorubicin. Its mode of action suggests a chelation of free radicals. In mice, dexrazoxane also offers protection against cardiac side effects of epirubicin, but not mitoxantrone.
Originator
Imperial Cancer Research Fund (United Kingdom)
Uses
Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.
Uses
Dexrazoxane has been used in chromatin remodelling experiments.
Uses
Cardioprotectant.
Definition
ChEBI: (+)-dexrazoxane is a razoxane. It has a role as a chelator, an antineoplastic agent, a cardiovascular drug and an immunosuppressive agent.
brand name
Zinecard (Pharmacia & Upjohn);Cardioxane.
General Description
Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs.
Biological Activity
Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.
Biochem/physiol Actions
Dexrazoxane is a cardioprotective compound against anthracyclines. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.
Clinical Use
Cardioxane? Prevention of cardiotoxicity in patients receiving doxorubicin or epirubicin for breast cancer Savene? : Treatment of extravasation caused by anthracyclines
Veterinary Drugs and Treatments
Dexrazoxane may be useful to attenuate the cardiotoxic effects of
doxorubicin in patients who are showing signs of anthracycline
cardiotoxicity, have cardiac disease, or are at maximum cumulative
dosages of doxorubicin. It is also used to treat extravasation injuries
associated with doxorubicin.
While dexrazoxane has been shown to be cardioprotective when
given at dosages of 10 times the doxorubicin dose, there is evidence
that it may also partially protect the cancer cells being treated.
Drug interactions
Potentially hazardous interactions with other drugs
Antiepileptics: may reduce absorption of
fosphenytoin and phenytoin.
Ciclosporin: increased risk of immunosuppression
with risk of lymphoproliferative disease.
Tacrolimus: increased risk of immunosuppression
with risk of lymphoproliferative disease.
Vaccines: risk of generalised infections with live
vaccines - avoid.
Metabolism
Dexrazoxane is hydrolysed by the enzyme
dihydropyrimidine amidohydrolase in the liver and
kidney to active metabolites that are capable of binding to
metal ions.
It is excreted unchanged via the kidney
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Dexrazoxane(24584-09-6)Related Product Information
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- ICRF 198
- N-(2-Amino-2-oxoethyl)-N-[(2S)-2-(3,5-dioxo-1-piperazinyl)propyl]-glycine
- 2,2',2'',2'''-[[(1S)-1-Methyl-1,2-ethanediyl]dinitrilo]tetrakisacetamide
- ICRF-186
- (S)-(+)-1,2-Diaminopropane-N,N,N',N'-tetraacetic acid
- Glycine, N-(2-amino-2-oxoethyl)-N-[(2R)-2-(3,5-dioxo-1-piperazinyl)propyl]-
- Glycine, N-(2-amino-2-oxoethyl)-N-[2-(3,5-dioxo-1-piperazinyl)propyl]-
- Dexrazoxane IMpurity D (N-oxide)
- Methyl