Basic information Safety Supplier Related

Dexrazoxane

Basic information Safety Supplier Related

Dexrazoxane Basic information

Product Name:
Dexrazoxane
Synonyms:
  • DEXRAZOXANE
  • (s)-4,4'-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione
  • 4’-(1-methyl-1,2-ethanediyl)bis-6-piperazinedion(+)-4
  • 4’-propylenedi-6-piperazinedion(+)-4
  • adr529
  • cardioxane
  • DEXTRAZOXANE
  • DEXTRORAZOXANE
CAS:
24584-09-6
MF:
C11H16N4O4
MW:
268.27
Product Categories:
  • API
  • Chelating Agent
Mol File:
24584-09-6.mol
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Dexrazoxane Chemical Properties

Melting point:
194-196°C
alpha 
D +11.35° (c = 5 in DMF)
Boiling point:
531.5±50.0 °C(Predicted)
Density 
1.333±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
powder
pka
2.1(at 25℃)
color 
white to off-white
Merck 
14,8123
InChIKey
BMKDZUISNHGIBY-ZETCQYMHSA-N
CAS DataBase Reference
24584-09-6(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
TL6390000
Hazardous Substances Data
24584-09-6(Hazardous Substances Data)
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Dexrazoxane Usage And Synthesis

Description

Dexrazoxane is the dextro-isomer of razoxane approved as a protectant against the cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the anticancer effect of doxorubicin. Its mode of action suggests a chelation of free radicals. In mice, dexrazoxane also offers protection against cardiac side effects of epirubicin, but not mitoxantrone.

Originator

Imperial Cancer Research Fund (United Kingdom)

Uses

Cardioprotectant.

brand name

Zinecard (Pharmacia & Upjohn);Cardioxane.

Biological Activity

Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.

Veterinary Drugs and Treatments

Dexrazoxane may be useful to attenuate the cardiotoxic effects of doxorubicin in patients who are showing signs of anthracycline cardiotoxicity, have cardiac disease, or are at maximum cumulative dosages of doxorubicin. It is also used to treat extravasation injuries associated with doxorubicin.
While dexrazoxane has been shown to be cardioprotective when given at dosages of 10 times the doxorubicin dose, there is evidence that it may also partially protect the cancer cells being treated.

DexrazoxaneSupplier

Liaoning bomei pharmaceutical technology co. LTD. Gold
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24-24524889
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sales@biosunpharm.com
Porton Fine Chemicals Gold
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023-86083200-6830
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yan.shangguan@porton.cn;
Wuhan Wsem Biological Co., Ltd. Gold
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027-83778876-
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13667159345@163.com
Jinan chenghui-shuangda chemical co.,ltd. Gold
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mahaiyan1123@126.com
Shanghai Boyle Chemical Co., Ltd.
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Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
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sales@boylechem.com