Basic information Safety Supplier Related

Dexrazoxane

Basic information Safety Supplier Related

Dexrazoxane Basic information

Product Name:
Dexrazoxane
Synonyms:
  • DEXRAZOXANE
  • (s)-4,4'-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione
  • 4’-(1-methyl-1,2-ethanediyl)bis-6-piperazinedion(+)-4
  • 4’-propylenedi-6-piperazinedion(+)-4
  • adr529
  • cardioxane
  • DEXTRAZOXANE
  • DEXTRORAZOXANE
CAS:
24584-09-6
MF:
C11H16N4O4
MW:
268.27
EINECS:
206-169-7
Product Categories:
  • API
  • Chelating Agent
  • 24584-09-6
Mol File:
24584-09-6.mol
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Dexrazoxane Chemical Properties

Melting point:
194-196°C
alpha 
D +11.35° (c = 5 in DMF)
Boiling point:
531.5±50.0 °C(Predicted)
Density 
1.333±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
powder
pka
2.1(at 25℃)
color 
white to off-white
Merck 
14,8123
InChIKey
BMKDZUISNHGIBY-ZETCQYMHSA-N
CAS DataBase Reference
24584-09-6(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
TL6390000
HS Code 
2933.59.9500
Hazardous Substances Data
24584-09-6(Hazardous Substances Data)
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Dexrazoxane Usage And Synthesis

Description

Dexrazoxane is the dextro-isomer of razoxane approved as a protectant against the cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the anticancer effect of doxorubicin. Its mode of action suggests a chelation of free radicals. In mice, dexrazoxane also offers protection against cardiac side effects of epirubicin, but not mitoxantrone.

Originator

Imperial Cancer Research Fund (United Kingdom)

Uses

Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.

Uses

Dexrazoxane has been used in chromatin remodelling experiments.

Uses

Cardioprotectant.

Definition

ChEBI: (+)-dexrazoxane is a razoxane. It has a role as a chelator, an antineoplastic agent, a cardiovascular drug and an immunosuppressive agent.

brand name

Zinecard (Pharmacia & Upjohn);Cardioxane.

General Description

Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs.

Biological Activity

Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.

Biochem/physiol Actions

Dexrazoxane is a cardioprotective compound against anthracyclines. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.

Clinical Use

Cardioxane? Prevention of cardiotoxicity in patients receiving doxorubicin or epirubicin for breast cancer Savene? : Treatment of extravasation caused by anthracyclines

Veterinary Drugs and Treatments

Dexrazoxane may be useful to attenuate the cardiotoxic effects of doxorubicin in patients who are showing signs of anthracycline cardiotoxicity, have cardiac disease, or are at maximum cumulative dosages of doxorubicin. It is also used to treat extravasation injuries associated with doxorubicin.
While dexrazoxane has been shown to be cardioprotective when given at dosages of 10 times the doxorubicin dose, there is evidence that it may also partially protect the cancer cells being treated.

Drug interactions

Potentially hazardous interactions with other drugs
Antiepileptics: may reduce absorption of fosphenytoin and phenytoin.
Ciclosporin: increased risk of immunosuppression with risk of lymphoproliferative disease.
Tacrolimus: increased risk of immunosuppression with risk of lymphoproliferative disease.
Vaccines: risk of generalised infections with live vaccines - avoid.

Metabolism

Dexrazoxane is hydrolysed by the enzyme dihydropyrimidine amidohydrolase in the liver and kidney to active metabolites that are capable of binding to metal ions.
It is excreted unchanged via the kidney

DexrazoxaneSupplier

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Porton Pharma Solutions Ltd. Gold
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Chongqing Bioland Pharmaceuticat Ltd. Gold
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Shanghai Boyle Chemical Co., Ltd.
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021-50182298 021-50180596
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