FRIEDELAN-3BETA-OL
FRIEDELAN-3BETA-OL Basic information
- Product Name:
- FRIEDELAN-3BETA-OL
- Synonyms:
-
- (3S,4R,4aS,6aS,6aS,6bR,8aR,12aR,14aS,14bS)-4,4a,6a,6b,8a,11,11,14a-octamethyl-1,2,3,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-hexadecahydropicen-3-ol
- FRIEDELAN-3BETA-OL
- LONGAN TRITERPANE A
- Epifriedelal
- Epifriedelinol
- 3beta-Hydroxyfriedelane
- 3-Epifriedelinol
- Epifriedelanol
- CAS:
- 16844-71-6
- MF:
- C30H52O
- MW:
- 428.73
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Miscellaneous Natural Products
- Mol File:
- 16844-71-6.mol
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FRIEDELAN-3BETA-OL Chemical Properties
- Melting point:
- 279-283 °C(Solv: chloroform (67-66-3))
- Boiling point:
- 478.3±13.0 °C(Predicted)
- Density
- 0.966±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 15.18±0.70(Predicted)
- color
- Off-White
- LogP
- 11.450 (est)
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FRIEDELAN-3BETA-OL Usage And Synthesis
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. Derived from Aster tataricus LF.
Uses
Epifriedelanol is a triterpenoid compound with antiproliferative and anti-cancer agent.
Definition
ChEBI: Epi-Friedelanol is a triterpenoid.
in vivo
Epifriedelanol (5-10 mg/kg; p.o.; 21 d) can against Bisphenol A (BPA) (HY-18260)-induced gonadotoxicity and has anti-inflammatory effects[3].
| Animal Model: | Male Sprague-Dawley rats, (180-200 g, age of 9-10 weeks)[3] |
| Dosage: | 5, 10 mg/kg |
| Administration: | Oral gavage (p.o.); 21 days |
| Result: | Showed a substantial decrease in prostate weight treated with Bisphenol A (BPA) (HY-18260), which could increase prostate size. Did not exhibit any detectable alterations in hematologic parameters when compared to the control group, supporting its biosafety and application in in vivo systems. Was preemptive against BPA-induced toxicity at both its high (10 mg/kg) and low (5 mg/kg) doses. Effectively retained physiological serum estradiol concentrations in a dose-dependent manner. Reduced peroxidation, and suppression of inflammatory markers (NO, IL-6 and TNF-α), indicating substantial antiinflammatory potential. |
FRIEDELAN-3BETA-OLSupplier
Chembest Research Laboratories Limited
- Tel
- +86-21-20908456
- sales@BioChemBest.com
BeiJing Hwrk Chemicals Limted
- Tel
- 0757-86329057 18934348241
- sales4.gd@hwrkchemical.com
China Langchem Inc.
- Tel
- 0086-21-58956006
BioBioPha Co., Ltd.
- Tel
- 0871-65217109 13211707573;
- y.liu@mail.biobiopha.com
Beijing HuaMeiHuLiBiological Chemical
- Tel
- 010-56205725
- waley188@sohu.com