1,2-NAPHTHOQUINONE Chemical Properties

Melting point:

139-142 °C (dec.) (lit.)

Boiling point:

243.22°C (rough estimate)

Density 

1.450 g/cm3 (25℃)

refractive index 

1.5300 (estimate)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), DMSO (Slightly)

form 

Crystalline Mass or Waxy Solid

color 

Colorless or white to pale yellow

Merck 

14,6394

BRN 

606546

Stability:

Light Sensitive

CAS DataBase Reference

524-42-5(CAS DataBase Reference)

EPA Substance Registry System

1,2-Naphthoquinone (524-42-5)

Safety Information

Hazard Codes 

Xn,Xi,C,F

Risk Statements 

22-36/37/38-34-11-25

Safety Statements 

26-36-45-36/37/39-16-37/39-28A

RIDADR 

2811

WGK Germany 

3

RTECS 

QL7000000

Hazard Note 

Irritant

HS Code 

29146990

Hazardous Substances Data

524-42-5(Hazardous Substances Data)

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

1,2-NAPHTHOQUINONE Usage And Synthesis

Chemical Properties

brown powder

Uses

Chemical reagent and intermediate.

Uses

1,2-Naphthquinone is a highly reactive quinone species which aids in modulating cellular homeostasis and electrophilic signal transduction pathways.

Uses

1,2-Naphthoquinone was employed as mediator during electrochemical mapping of redox activity in normal human breast (MCF-10A) cells by scanning electrochemical microscopy (SECM).

Definition

ChEBI: 1,2-naphthoquinone is the parent structure of the family of 1,2-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 2 of the naphthalene ring. It is a metabolite of naphthalene and is found in diesel exhaust particles. It has a role as a carcinogenic agent and an aryl hydrocarbon receptor agonist. It derives from a hydride of a naphthalene.

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 603, 1984 DOI: 10.1016/S0040-4039(00)99949-0
The Journal of Organic Chemistry, 51, p. 5390, 1986 DOI: 10.1021/jo00376a061

General Description

Golden yellow needles or brown powder. Decomposes to a bluish-black color on standing.

Air & Water Reactions

The neat chemical may be sensitive to prolonged exposure to air and light. Insoluble in water.

Reactivity Profile

Ketones, such as 1,2-NAPHTHOQUINONE, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Hazard

Irritant

Health Hazard

ACUTE/CHRONIC HAZARDS: 1,2-NAPHTHOQUINONE is an irritant. When heated to decomposition it emits acrid smoke and fumes.

Fire Hazard

Flash point data for 1,2-NAPHTHOQUINONE are not available. 1,2-NAPHTHOQUINONE is probably combustible.

Purification Methods

Crystallise the quinone from ether (red needles) or *benzene (orange leaflets). [Beilstein 7 IV 2417.]

1,2-NAPHTHOQUINONE(524-42-5)Related Product Information

• 4-Chloro-1,2-naphthalenedione
• 1,2-Naphthoquinone-4-sulfoni
• POTASSIUM 1,2-NAPHTHOQUINONE-4-SULFONIC ACID
• DIHYDROTANSHINONE
• 1,2-NAPHTHOQUINONE
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• Menadione
• 1,4-Naphthoquinone, 2-hydroxy-,2-hydroxy-4-naphthoquinon
• 1,2-NAPHTHOQUINONE-2-DIAZIDO-4-SULFONYL CHLORIDE
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• 5,12-NAPHTHACENEQUINONE
• SODIUM 1,2-NAPHTHOQUINONE-2-DIAZIDO-5-SULFONATE
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• 2,3,4,4'-Tetrahydroxybenzophenone 1,2-naphthoquinonediazido-5-sulfonate
• 1 3-BIS(2 6-DIISOPROPYLPHENYL)IMIDAZOL-&