2-mercapto-N-methylbenzamide Chemical Properties

Melting point:

94-96 °C

Boiling point:

326.2±25.0 °C(Predicted)

Density 

1.174

storage temp. 

2-8°C

solubility 

Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)

pka

5.89±0.43(Predicted)

form 

Solid

color 

Off-White to Pale Beige

Stability:

Air Sensitive

LogP

1.360 (est)

Safety Information

HS Code 

2930909899

2-mercapto-N-methylbenzamide Usage And Synthesis

Description

N-methyl-2-sulfanylbenzamide is an axitinib intermediate.

Uses

2-Mercapto-N-methyl-benzamide is an intermediate used to prepare axitinib (A794650) which is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

Application

2-Mercapto-N-methyl-benzamide is an intermediate used to prepare axitinib which is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

Synthesis

2-mercapto-N-methylbenzamide is prepared by reactig 2,2'-Disulfanediylbis(N-methylbenzamide) and sodium tetrahydroborate In tetrahydrofuran.

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