ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > FIPI
FIPI
FIPI Basic information
- Product Name:
- FIPI
- Synonyms:
-
- FIPI
- FIPI HYDROCHLORIDE
- 5-Fluoro-2-Indolyl des-Chlorohalopemide
- N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide
- N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride
- CS-1511
- 5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide
- 1H-Indole-2-carboxamide, N-[2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-
- CAS:
- 939055-18-2
- MF:
- C23H24FN5O2
- MW:
- 421.47
- Mol File:
- 939055-18-2.mol
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FIPI Chemical Properties
- Density
- 1.349±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 14.67 mg/mL (34.81 mM; Need ultrasonic and warming)
- form
- Powder
- pka
- 12.04±0.30(Predicted)
- color
- Light yellow to khaki
- SMILES
- O=C(C1=CC2=C(C=CC(F)=C2)N1)NCCN3CCC(N4C(NC5=C4C=CC=C5)=O)CC3
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FIPI Usage And Synthesis
Uses
FIPI is a a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis.
Definition
ChEBI: FIPI is a member of benzimidazoles.
in vivo
FIPI (3 mg/kg; intraperitoneal injection; 2 times) shows protective effect in carotid thrombosis model and ischemic stroke model[4].
| Animal Model: | Ferric chloride (HY-Y0266) or transient middle cerebral artery occlusion treated mice[4] |
| Dosage: | 3 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); 2 times, 12 h apart |
| Result: | Delayed the thrombus formation and only 3 of 9 vessels occluded during the 30-minute observation period in arterial thrombosis models. Reduced the infarct volumes, improved motor and overall nerve function and did not impair normal hemostasis in ischemic stroke models. |
IC 50
PLD1; PLD2
FIPISupplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
Acesys Pharmatech
- Tel
- 18860950986
- tangmanman@zenjipharma.com
AdooQ BioScience, LLC
- Tel
- +1 (866) 930-6790
- info@adooq.com
Bide Pharmatech Ltd.
- Tel
- 400-400-164-7117 18317119277
- product02@bidepharm.com