6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Chemical Properties

Density 

1.32

storage temp. 

Store at -20°C

solubility 

insoluble in EtOH; insoluble in H2O; ≥14.4 mg/mL in DMSO

form 

Powder

pka

9.94±0.10(Predicted)

color 

Light yellow to yellow

6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Usage And Synthesis

Biological Activity

the interleukin-1 receptor associated kinase (irak) family is comprised of four family members irak-1, irak-2, irak-3/m, and irak-4. upon activation of their upstream cognate receptors, irak-4 is thought to phosphorylate irak-1 resulting in the activation and autophosphorylation of irak-1 an subsequent phosphorylation of downstream substrates. irak inhibitor 1 is an inhibitor of interleukin-1 receptor associated kinase 4 (irak-4).

in vitro

the regioisomeric pyridines irak inhibitor 1 (6) and it analogue (7) showed contrasting sar, with the 2,6-pyridine isomer irak inhibitor 1 having low-nanomolar potency whilst the 2,4-pyridine isomer 7 showed little activity, despite having a more accessible bidentate-binding motif. at 10 μm, irak inhibitor 1 was found to have 39% inhibition for jnk-1 and 15% inhibition for jnk-2, respectivley [1].

target

IRAK-4

IC 50

35 nm for irak-4

References

[1] buckley gm, ceska ta, fraser jl, gowers l, groom cr, higueruelo ap, jenkins k, mack sr, morgan t, parry dm, pitt wr, rausch o, richard md, sabin v. irak-4 inhibitors. part ii: a structure-based assessment of imidazo[1,2-a]pyridine binding. bioorg med chem lett. 2008;18(11):3291-5.

6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine(1042224-63-4)Related Product Information

• libaotao
• Urease inhibitor
• Veliparib
• NS-398
• IRAK-1/4 INHIBITOR I
• N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide
• 4-[[[3-(3,4-Dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]methyl]benzenesulfonamide
• 4-[6-[[(Furan-2-yl)methyl]amino]imidazo[1,2-b]pyridazin-3-yl]phenol