GLIOVIRIN Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO: soluble,Ethanol: soluble,Methanol: soluble

form 

A solid

Safety Information

HS Code 

2941900000

GLIOVIRIN Usage And Synthesis

Description

Gliovirin is a fungal metabolite that has been found in T. harzianum and has fungicidal, antimicrobial and anti-inflammatory activities. It is active against the plant pathogenic fungus P. ultimum (MIC = 60 ng/ml) and the parasite T. brucei brucei (IC₅₀ = 90 ng/ml), but has no effect on the plant pathogenic fungi R. solani, P. omnivorum, T. basicola, R. arrhizus, and V. dahliae or the bacteria B. thuringiensis, P. fluorescens, and X. malvacearum when used at concentrations up to 1,000 ng/ml. Gliovirin decreases phorbol 12-myristate 13-acetate (TPA)- and ionomycin-induced increased expression of COX-2 (IC₅₀ = 1 μM) and protein levels of IL-2 in Jurkat cells (IC₅₀ = 5.2 μM).

References

[1] JAN RETHER. Inhibition of inducible tumor necrosis factor-alpha expression by the fungal epipolythiodiketopiperazine gliovirin.[J]. Biological Chemistry, 2007, 388 6: 627-637. DOI: 10.1515/bc.2007.066
[2] HOWELL C R, STIPANOVIC R. Gliovirin, a new antibiotic from Gliocladium virens, and its role in the biological control of Pythium ultimum[C]//57 1. 1983: 0. DOI: 10.1139/m83-053
[3] MASATO IWATSUKI. In vitro antitrypanosomal activity of 12 low-molecular-weight antibiotics and observations of structure/activity relationships[J]. Journal of Antibiotics, 2010, 63 10: 619-622. DOI: 10.1038/ja.2010.99

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