FLI-06 Chemical Properties

Melting point:

199-202oC

Boiling point:

597.5±50.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: soluble5mg/mL, clear (warmed)

form 

powder

pka

0.78±0.70(Predicted)

color 

white to beige

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.

Safety Information

RIDADR 

3077

WGK Germany 

3

HS Code 

29339900

FLI-06 Usage And Synthesis

Description

FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from that of brefeldin A. It inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER. Thus FLI-06 is the first small molecule acting at such an early stage in secretory traffic.1

Uses

FLI-06 is a novel inhibitor of Notch signalling and the early secretory pathway.

References

1) Kramer?et al., (2013),?Small molecules intercept Notch signaling and the early secretory pathway; Nat. Chem. Biol.?9 731

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