1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine hydrochloride Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO : ≥ 73 mg/mL (206.30 mM)

form 

Solid

color 

Light yellow to khaki

1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine hydrochloride Usage And Synthesis

Uses

1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases. 1-Naphthyl PP1 hydrochloride inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively[1].

References

[1] Tandon M, et al. New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. PLoS One. 2013 Sep 23;8(9):e75601. DOI:10.1371/journal.pone.0075601
[2] Bishop AC, et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21;407(6802):395-401. DOI:10.1038/35030148

1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine hydrochloride(956025-47-1)Related Product Information

• Pyrazole
• 2-Chloro-2-methylpropane
• 2-Bromo-2-methylpropane
• 3,3-Dimethyl-1-butyne