HG-14-10-04 Chemical Properties

Boiling point:

761.1±70.0 °C(Predicted)

Density 

1.297±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 13.3 mg/mL (25.00 mM; Need ultrasonic and warming)

form 

Powder

pka

14.62±0.30(Predicted)

color 

Light yellow to yellow

HG-14-10-04 Usage And Synthesis

Uses

HG-14-10-04 is a potent ALK and mutant EGFR inhibitor with IC50s of 20 nM, 15.6 nM, 22.6 nM and 124.5 nM for ALK, EGFRLR/TM, EGFR19del/TM/CS and EGFRLR/TM/CS, respectively. HG-14-10-04 can be used to research anticancer[1][2].

Definition

ChEBI: 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2-pyrimidinamine is a member of piperidines.

IC 50

EGFR^LR/TM: 15.6 nM (IC₅₀); EGFR^19del/TM/CS: 22.6 nM (IC₅₀); EGFR^LR/TM/CS: 124.5 nM (IC₅₀); ALK: 20 nM (IC₅₀)

References

[1] U.S. Pat. Appl. Publ. (2012), US 20120028924 A1
[2] Chen H, et al. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65(9):6840-6858. DOI:10.1021/acs.jmedchem.2c00168

HG-14-10-04(1356962-34-9)Related Product Information

• [4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone