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BMH21

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BMH21 Basic information

Product Name:
BMH21
Synonyms:
  • BMH21
  • N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
  • BMH-21 N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
  • N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
  • CS-1749
  • BMH 21;BMH21
  • BMH-21, >98%
  • 12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo-
CAS:
896705-16-1
MF:
C21H20N4O2
MW:
360.41
EINECS:
809-833-1
Product Categories:
  • Inhibitors
Mol File:
896705-16-1.mol
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BMH21 Chemical Properties

storage temp. 
2-8°C
solubility 
DMSO: soluble1mg/mL, clear (warmed)
form 
powder
color 
light yellow to dark yellow
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
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BMH21 Usage And Synthesis

Uses

BMH-21 has been used in cell culture.

General Description

BMH-21 is a planar heterocyclic small molecule DNA intercalator.

Biochem/physiol Actions

BMH-21 is a potent inhibitor of RNA Pol I. BMH-21 binds strongly to GC-rich DNA sequences, ultimately inhibiting RNA Pol I, blocking transcription and disrupting the nucleolar structure. BMH-1 causes dissociation of the RPA194 catalytic subunit from Pol I, and disassembly of Pol I:DNA complexes. The compound BMH-21 inhibits proliferation of a broad range of tumor cell lines.

BMH21Supplier

Shanghai Boyle Chemical Co., Ltd.
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Dalian Meilun Biotech Co., Ltd.
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Haoyuan Chemexpress Co., Ltd.
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AdooQ BioScience, LLC
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TargetMol Chemicals Inc.
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