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ZLN-024

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ZLN-024 Basic information

Product Name:
ZLN-024
Synonyms:
  • 2-[2-(2-bromo-4-methylphenoxy)ethylsulfanyl]pyrimidine
  • ZLN024
  • ZLN-024
  • 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]-pyrimidine
  • Pyrimidine, 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-
  • Inhibitor,AMPK,AMP-activated protein kinase,inhibit,ZLN024,ZLN 024,ZLN-024
  • ZLN024, 10 mM in DMSO
  • ZLN-024 (ZLN024)
CAS:
723249-01-2
MF:
C13H13BrN2OS
MW:
325.22
Mol File:
723249-01-2.mol
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ZLN-024 Chemical Properties

Boiling point:
443.3±35.0 °C(Predicted)
Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
0.12±0.33(Predicted)
color 
white to beige
InChI
1S/C13H13BrN2OS/c1-10-3-4-12(11(14)9-10)17-7-8-18-13-15-5-2-6-16-13/h2-6,9H,7-8H2,1H3
InChIKey
KWJRSHZSULRJHE-UHFFFAOYSA-N
SMILES
S(CCOc2c(cc(cc2)C)Br)c1ncccn1
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
WGK Germany 
3
Storage Class
11 - Combustible Solids
Hazard Classifications
Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
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ZLN-024 Usage And Synthesis

Uses

ZLN024 is a useful chemical reagent.

Biological Activity

ZLN024 is an allosteric activator of AMPK hetero-trimers. The compound ZLN024 protects against dephosphorylation of Thr172, which is critical for activity, and antagonizes AMPK autoinhibition. ZLM024 improves glucose tolerance and lowers total cholesterol levels in db/db mice.

in vivo

C57BKS db/db mice are administered a 15 mg/kg/day dose of ZLN024 by daily gavage for 5 weeks; 250 mg/kg/day Metformin (Met) is used as a positive control. During the treatment period, there is no significant alteration in food intake and body weight compared with the vehicle group. After 4 weeks of treatment, ZLN024 improves glucose tolerance. ZLN024 reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content are decreased[1].

IC 50

AMPK α2β2γ1: 0.13 μM (EC50); AMPK α1β1γ1: 0.42 μM (EC50); AMPK α2β1γ1: 0.95 μM (EC50)

ZLN-024Supplier

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