Basic information Safety Supplier Related

CYCLO(-HIS-PRO)

Basic information Safety Supplier Related

CYCLO(-HIS-PRO) Basic information

Product Name:
CYCLO(-HIS-PRO)
Synonyms:
  • (3S,6S)-3-(3H-imidazol-4-ylmethyl)-1,4-diazabicyclo[4.4.0]decane-2,5-dione
  • Histidylproline diketopiperazine
  • histidylproline dioxopiperazine
  • Cyclo-Pro-His-HO
  • HIS-PRO, CYCLIC
  • CYCLO(-HIS-PRO)
  • Cyclo(histidyl-proline)
  • CYCLO(HISTIDYL-PROLINE); HISTIDYLPROLINE DIKETOPIPERAZINE
CAS:
53109-32-3
MF:
C11H14N4O2
MW:
234.25
Mol File:
53109-32-3.mol
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CYCLO(-HIS-PRO) Chemical Properties

Melting point:
162-164 °C
Boiling point:
659.3±48.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml
form 
A neat oil
pka
12.73±0.40(Predicted)
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Safety Information

WGK Germany 
3

MSDS

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CYCLO(-HIS-PRO) Usage And Synthesis

Uses

Cyclo(L-histidyl-L-proline) is used in the pharmaceutical composition comprising cyclo(His-Pro) for preventing or treating obesity.

Definition

ChEBI: Cyclo(L-His-L-Pro) is a homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH). It has a role as a human blood serum metabolite, a dopamine uptake inhibitor and an anti-inflammatory agent. It is a homodetic cyclic peptide, a dipeptide, a pyrrolopyrazine and a member of imidazoles. It is functionally related to a L-histidine and a L-proline.

CYCLO(-HIS-PRO)Supplier

Hangzhou Sinoda Pharmaceutical Technology Co. LTD Gold
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17306812703
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3007955328@qq.com
GL Biochem (Shanghai) Ltd
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21-61263452 13641803416
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ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696;
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info@hanhongsci.com
Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
Wuxi Zhongkun Biochemical Technology Co., Ltd.
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0510-85629785 18013409632
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sales@reading-chemicals.com