CYCLO(-HIS-PRO) Chemical Properties

Melting point:

162-164 °C

Boiling point:

659.3±48.0 °C(Predicted)

Density 

1.41±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml

form 

A neat oil

pka

12.73±0.40(Predicted)

color 

Light yellow to yellow

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

CYCLO(-HIS-PRO) Usage And Synthesis

Uses

Cyclo(L-histidyl-L-proline) is used in the pharmaceutical composition comprising cyclo(His-Pro) for preventing or treating obesity.

Definition

ChEBI: Cyclo(L-His-L-Pro) is a homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH). It has a role as a human blood serum metabolite, a dopamine uptake inhibitor and an anti-inflammatory agent. It is a homodetic cyclic peptide, a dipeptide, a pyrrolopyrazine and a member of imidazoles. It is functionally related to a L-histidine and a L-proline.

CYCLO(-HIS-PRO)(53109-32-3)Related Product Information

• 2,5-Dimethylpiperazine
• 1-Methylpiperazin-2-one
• DL-2-AMINOPROPIONIC ANHYDRIDE
• CYCLO(-ALA-ALA)
• CIS-2,5-DIMETHYLPIPERAZINE
• CYCLO-(D-PRO-L-ALA-D-ALA-L-2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID),Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-]
• Cyclo(L-Pro-L-Val-)
• CYCLO(-GLY-HIS)
• 1-ETHYL-2-METHYL-PIPERAZINE
• CYCLO(-GLY-PRO)
• (S)-3-METHYL-2-KETOPIPERAZINE
• CYCLO(-ALA-GLY)
• HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE
• (+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE
• (R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE
• 1-ETHYLPIPERAZIN-2-ONE
• hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one
• (S)-1,4-DIAZABICYCLO[4.3.0]NONANE