PHENACETIN-ETHOXY-1-13C Chemical Properties

Melting point:

134-136 °C(lit.)

form 

solid

CAS Number Unlabeled

62-44-2

Safety Information

Hazard Codes 

T

Risk Statements 

45-46-20/21/22-22

Safety Statements 

53-22-36/37/39-45

WGK Germany 

3

MSDS

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PHENACETIN-ETHOXY-1-13C Usage And Synthesis

Uses

Phenacetin-13C is the 13C labeled Phenacetin[1]. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[2][3][4].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Chandrasekharan NV, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13926-31. DOI:10.1073/pnas.162468699
[3] Xiao-Meng He, et al. Effects of long-term smoking on the activity and mRNA expression of CYP isozymes in rats. J Thorac Dis. 2015 Oct 7(10): 1725–1731. DOI:10.3978/j.issn.2072-1439.2015.10.07
[4] Na Gao, et al. Inhibition of Baicalin on Metabolism of Phenacetin, a Probe of CYP1A2, in Human Liver Microsomes and in Rats. PLoS One. 2014 9(2): e89752. DOI:10.1371/journal.pone.0089752

PHENACETIN-ETHOXY-1-13C(72156-72-0)Related Product Information

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• PHENACETIN-ETHOXY-1-13C,PHENACETIN-ETHOXY-2-13C, 99 ATOM % 13C
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