ACETOACETYL COENZYME A SODIUM SALT HYDRATE Chemical Properties

storage temp. 

−20°C

solubility 

H₂O: 50 mg/mL, clear, colorless to faintly yellow

Safety Information

WGK Germany 

3

F 

10-21

MSDS

• Language:English Provider:SigmaAldrich

ACETOACETYL COENZYME A SODIUM SALT HYDRATE Usage And Synthesis

Description

Acetoacetyl-coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway. It is reversibly converted to acetyl-CoA by acetoacetyl-CoA thiolase in the mitochondria. Acetoacetyl-CoA thiolase (T2) deficiency results in a build-up of ketone bodies leading to intermittent ketoacidosis. Acetoacetyl-CoA is also an intermediate in the microbial biosynthesis of polyhydroxybutyrate.

References

[1] OCHOA S. Enzymes of fatty acid metabolism: a commentary on “Enzymes of Fatty Acid Metabolism”.[J]. Biochimica et biophysica acta, 1989, 1000: 279-280.
[2] MIZIORKO H M. Enzymes of the mevalonate pathway of isoprenoid biosynthesis[J]. Archives of biochemistry and biophysics, 2011, 505 2: Pages 131-143. DOI: 10.1016/j.abb.2010.09.028
[3] R S DAUM. An inherited disorder of isoleucine catabolism causing accumulation of alpha-methylacetoacetate and alpha-methyl-beta -hydroxybutyrate, and intermittent metabolic acidosis.[J]. Pediatric Research, 1973, 7 3: 149-160. DOI: 10.1203/00006450-197303000-00007
[4] TOSHIYUKI FUKAO . The Clinical Phenotype and Outcome of Mitochondrial Acetoacetyl-CoA Thiolase Deficiency (β-Ketothiolase or T2 Deficiency) in 26 Enzymatically Proved and Mutation-Defined Patients[J]. Molecular genetics and metabolism, 2001, 72 2: Pages 109-114. DOI: 10.1006/mgme.2000.3113
[5] NICOLAS JACQUEL . Isolation and purification of bacterial poly(3-hydroxyalkanoates)[J]. Biochemical Engineering Journal, 2008, 39 1: Pages 15-27. DOI: 10.1016/j.bej.2007.11.029

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