DC_05 Chemical Properties

Boiling point:

667.5±55.0 °C(Predicted)

Density 

1.23±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 12 mg/ml; DMSO: 11 mg/ml; Ethanol: Slightly soluble; PBS (pH 7.2): 0.3 mg/ml

form 

A solid

pka

13.72±0.20(Predicted)

color 

White to off-white

DC_05 Usage And Synthesis

Uses

DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 10.3 μM and 1.09 μM, respectively.

IC 50

DNMT1: 1.09 μM (Kd); DNMT1: 10.3 μM (IC₅₀); PRMT1: 37.1 μM (IC₅₀)

References

[1] Chen S, et al. Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening. J Med Chem. 2014 Nov 13;57(21):9028-41. DOI:10.1021/jm501134e