Basic information Chemical properties Uses Toxicity Usage limit Production method Hazards & Safety Information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Fluid, Electrolyte, and Acid-Base Balance >  Electrolyte Balance Pharmacology >  Calcium acetate

Calcium acetate

Basic information Chemical properties Uses Toxicity Usage limit Production method Hazards & Safety Information Safety Supplier Related

Calcium acetate Basic information

Product Name:
Calcium acetate
Synonyms:
  • acetatedecalcium
  • Aceticacid,calciunsalt
  • teltozan
  • vinegarsalts
  • CALCIUM ACETATE EXTRA PURE, FCC, E 263
  • CALCIUM ACETATE HYDRATE PURE
  • CALCIUM ACETATE HYDRATE, 99.99%
  • CALCIUM ACETATE SIGMAULTRA
CAS:
62-54-4
MF:
C4H6CaO4
MW:
158.17
EINECS:
200-540-9
Product Categories:
  • Organic chemistry
  • Pyridines
  • metal acetate salt
  • Food additive
  • food stabilizer,corrosion inhibitor
  • other chemicals
  • 62-54-4
Mol File:
62-54-4.mol
More
Less

Calcium acetate Chemical Properties

Melting point:
160°C (dec.)
Density 
1,5 g/cm3
refractive index 
1.5500
FEMA 
2228 | CALCIUM ACETATE
Flash point:
160°C
storage temp. 
Hygroscopic, Room Temperature, under inert atmosphere
solubility 
H2O: 1 M at 20 °C, clear, colorless
form 
Powder
Specific Gravity
1.50
color 
white
PH
8(1 mM solution);8.43(10 mM solution);8.77(100 mM solution);9.13(1000 mM solution)
Water Solubility 
soluble
Decomposition 
160 ºC
Stability:
Stable. Non-flammable. Incompatible with strong oxidizing agents.
InChIKey
VSGNNIFQASZAOI-UHFFFAOYSA-L
CAS DataBase Reference
62-54-4(CAS DataBase Reference)
EPA Substance Registry System
Calcium acetate (62-54-4)
More
Less

Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
1
RTECS 
AF7525000
TSCA 
Yes
HS Code 
29152990
Hazardous Substances Data
62-54-4(Hazardous Substances Data)

MSDS

More
Less

Calcium acetate Usage And Synthesis

Chemical properties

Calcium acetate, also known as acetate of lime or vinegar salts, is the calcium salt of acetic acid. It is an odorless powder. Calcium has an important role in the nutrition of humans and animals. Hormonal mechanisms control absorption of dietary calcium (including added calcium salts) allowing adaptation to a range of calcium intakes while maintaining a relatively constant blood calcium concentration of about 10 mg/100 mL. Major functions of calcium inside the body include the formation and maintenance of bones and teeth, the physiology of muscle contraction, the cell membrane integrity, the activity of several enzymes that have specific requirement for it, the coagulation of blood, and the regulation of acid-base balance.*

Uses

Calcium acetate [Ca(CH3COO)2.H2O] is used as a food additive and a mordant to fix dyes in the textile industry. It is used as an alkali (base) in the manufacture of soaps, to improve some lubricants, and as an antimold to preserve baked goods for a longer shelf life.

Toxicity

ADI is not subject to restrictive regulations (FAO/WHO, 2001).
GRAS (FDA, §181.29, §182.6197, § 184.1185, 2000).
LD50: 52 mg/kg (mouse, subcutaneous).

Usage limit

GB 14880 a 94: cereals and their products, beverages 8~16g/kg.
GB 2760-2001: vinegar, 6~8g/kg (in terms of Ca).
FAO/WHO (1984): Edible caseinate, GMP.
FDA, § 184.1185 (2000): baked goods, gelatin, pudding, fillings, 0.2%; sweet sauce, top materials and poured, 0.15%;
EEC can be used for packaging cheese powder, quick-setting jelly powder.
FEMA (mg/kg): soft drinks 200; baked goods 500.

Production method

It is obtained by the reaction between calcium carbonate and acetic acid. Preparation method of anhydrous calcium acetate: the refined powder of calcium carbonate is added to the water, stirred into a suspension; added separately of a small amount of glacial acetic acid. After completion of the reaction, the filtrate was concentrated in a water bath and a white solid, anhydrous calcium acetate, was precipitated from the viscous filtrate.
It is obtained by the neutralization between coke acid (wood acetic acid) and calcium hydroxide, followed by the evaporation of the filtrate and recrystallization.
It is obtained by the reaction between the reaction between acetic acid and calcium hydroxide or calcium carbonate. Filter, concentrate and cool to obtain the dihydrate (colorless crystal), heated to 84 °C in a water salt (colorless crystal), heated to 100 °C to obtain the anhydrous salt.
Shellfish can be taken as raw materials, washed, crushed and dried for 1 h, subjecting to barbecue for 2 hour at 900~l000 ℃, then being added water to make a 1.3~1.5mol/L lime milk. And then neutralized with acetic acid to clarify, filter with the filtrate concentrated, and finally dried at 120~140 °C to get the final product with a yield of 91.28%.
To a 20% acetic acid solution, add calcium carbonate powder to until there is no longer any CO2 gas escaping, then add a small amount of calcium carbonate, heated  80 ° C for reaction of 2-3h. The filtrate was heated and concentrated with water bath while adding a small amount of 80% acetic acid at the same time to precipitate the calcium acetate monohydrate (what precipitated after the cooling of the solution is dihydrate), and finally dried at 60~70 ℃to derive the products.

Hazards & Safety Information

Category:  Toxic substances
Toxicity classification:  highly toxic
Acute toxicity:  intravenous-mouse LD50: 52 mg/kg; celiac-mouse LD50: 75 mg/kg
Flammability and Hazardous characteristics:  Thermal decomposition releases Pungent irritation Smoke
Storage and transportation characteristics:Treasury: ventilated, low temperature drying; store it separately from food raw materials
Fire extinguishing agent:  water, dry powder, foam, carbon dioxide

Description

Calcium acetate is a chemical compound which is calcium salt of acetic acid. It has the formula Ca(C2H3O2)2. Its standard name is calcium acetate, while calcium ethanoate is the systematic name. An older name is acetate of lime. The anhydrous form is very hygroscopic; therefore the monohydrate (Ca(CH3COO)2?H2O) is the common form.

Chemical Properties

Calcium acetate occurs as a white or almost white, odorless or almost odorless, hygroscopic powder.

Uses

Calcium Acetate is the calcium salt of acetic acid which functions as a sequestrant and mold control agent. it contains approximately 25% calcium. it is a white odorless powder which is readily soluble in water with a solubility of approximately 37 g in 100 g water at 0°c. its solubility decreases with increasing temperature, with a sol- ubility of approximately 29 g in 100 g of water at 100°c.

Uses

Calcium Acetate is the salt of acetic acid which is used as a preservative and sequestrant.

Uses

Calcium Acetate is a salt of acetic acid (A167640), a common chemical reagent used in a multitude of organic reactions. It is the primary constituent of vinegar, contributing to its distinct taste and odor. It is used in the synthesis of dye-sensitized solar cells.

Production Methods

Calcium acetate can be prepared by soaking calcium carbonate (found in eggshells, or in common carbonate rocks such as lime stone or marble) in vinegar:
CaCO3 + 2CH3COOH → Ca(CH3COO)2 + H2O + CO2
Since both reagents would have been available pre-historically, the chemical would have been observable as crystals then.

Preparation

Produced by calcium hydroxide neutralization of acetic acid.

Definition

ChEBI: The calcium salt of acetic acid. It is used, commonly as a hydrate, to treat hyperphosphataemia (excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form (insoluble) calcium phosphate, which is excreted in the faeces.

General Description

Calcium Acetate belongs to the group of calcium salts, widely used as phosphorus binders in patients with chronic renal failure.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Pharmaceutical Applications

Calcium acetate is used as a preservative in oral and topical formulations.
Therapeutically, parenteral calcium acetate acts as a source of calcium ions for hypocalcemia or electrolyte balance. Oral calcium acetate is used as a complexing agent for hyperphosphatemia in dialysis patients. Calcium acetate is also used in the food industry as a stabilizer, buffer and sequestrant.

Clinical Use

Phosphate binding agent

Safety Profile

Poison by intravenous and intraperitoneal routes. Mutation data reported. See also CALCIUM COMPOUNDS. When heated to decomposition it emits acrid smoke and fumes.

Safety

Calcium acetate is used in oral and topical formulations. The pure form of calcium acetate is toxic by IP and IV routes.
LD50 (mouse, IP): 0.075 g/kg
LD50 (mouse, IV): 0.052 g/kg
LD50 (rat, oral): 4.28 g/kg

Veterinary Drugs and Treatments

Calcium acetate can be used for oral administration to treat hyperphosphatemia in patients with chronic renal failure. Secondary to its phosphorus binding efficiency and lower concentration of elemental calcium, calcium acetate is considered the most effective and having the lowest potential for causing hypercalcemia of the calcium-based phosphorus-binding agents. When compared to calcium carbonate, calcium acetate binds approximately twice as much phosphorus per gram of elemental calcium administered. Unlike calcium citrate, calcium acetate does not promote aluminum absorption.

Drug interactions

Potentially hazardous interactions with other drugs
Can impair absorption of some drugs, e.g. iron, ciprofloxacin.

Metabolism

The residual acetate will be metabolised through bicarbonate, which will be further excreted via normal metabolic routes. Any unbound calcium not involved in the binding of phosphate will be variable and may be absorbed. Calcium is absorbed mainly from the small intestine by active transport and passive diffusion. About one-third of ingested calcium is absorbed although this can vary depending upon dietary factors and the state of the small intestine. 1,25-Dihydroxycholecalciferol (calcitriol), a metabolite of vitamin D, enhances the active phase of absorption. Excess calcium is mainly excreted renally. Unabsorbed calcium is eliminated in the faeces, together with that secreted in the bile and pancreatic juice. Minor amounts are lost in the sweat, skin, hair, and nails.

storage

Calcium acetate is stable although very hygroscopic, and so the monohydrate is the common form. It decomposes on heating (above 1608℃) to form calcium carbonate and acetone.
Store in well-closed airtight containers.

Purification Methods

Recrystallise it from water (3mL/g) by partial evaporation in a desiccator. [Beilstein 2 IV 113.]

Incompatibilities

Calcium acetate is incompatible with strong oxidizing agents and moisture.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral suspensions and tablets; topical emulsions, lotions, and creams). Included in nonparenteral medicines (oral tablets) licensed in the UK.

Calcium acetateSupplier

Shanghai Bihe Biochemical Technology Co., Ltd Gold
Tel
021-60769171-8001 15900991383
Email
cici@bihebio.com
Products Intro
Product Name:Calcium acetate
CAS:62-54-4
Purity:98% Package:1kg;5kg;10kg;25kg
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Products Intro
Product Name:Calcium acetate, 99%
CAS:62-54-4
Purity:99% Package:500G
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169121
Email
market03@meryer.com
Products Intro
Product Name:CALCIUM ACETATE, Monohydrate
CAS:62-54-4
Package:100g;2kg Remarks:CXCA010
Energy Chemical
Tel
021-58432009 400-005-6266
Email
sales8178@energy-chemical.com
Products Intro
Product Name:Calcium acetate
CAS:62-54-4
Purity:99% Package:250g;100g;500g;10g;25g
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Email
2355560935@qq.com
Products Intro
Product Name:Calcium acetate
CAS:62-54-4
Purity:98% Package:10g;50g;100g;250g;500g