ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > PF-04929113 (Mesylate)
PF-04929113 (Mesylate)
PF-04929113 (Mesylate) Basic information
- Product Name:
- PF-04929113 (Mesylate)
- Synonyms:
-
- SNX5422 Mesylate
- SNX-5422 Mesylate
- SNX-5422 MESYLATE;PF04929113 MESYLATE;SNX5422 MESYLATE
- PF-04929113 (Mesylate)
- (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl 2-aminoacetate methanesulfonate
- SNX-5422 MESYLATE (PF-04929113 MESYLATE)
- trans-4-((2-Carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate methanesulfonate
- PF 04929113 Mesylate,PF04929113 Mesylate
- CAS:
- 1173111-67-5
- MF:
- C26H34F3N5O7S
- MW:
- 617.64
- Mol File:
- 1173111-67-5.mol
More
Less
PF-04929113 (Mesylate) Chemical Properties
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO:46.85(Max Conc. mg/mL);75.85(Max Conc. mM)
More
Less
PF-04929113 (Mesylate) Usage And Synthesis
Uses
PF-04929113 (Mesylate) functions as a potent and selective Hsp90 inhibitor. Substances in the discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
in vivo
SNX-5422 (50 mg/kg, p.o.) efficiently inhibits tumor growth of HT-29 human colon tumor xenograft model after administration 3 times a week for 3 weeks (qod × 3/2 × 3)[1]. SNX-5422 (20, 40 mg/kg, p.o.) markedly inhibits multiple myeloma (MM) tumor growth and angiogenesis in mice[2].
IC 50
HSP90: 41 nM (Kd)
PF-04929113 (Mesylate)Supplier
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
- Tel
- 025-66113011 17798518460
- cfzhang@aikonchem.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Jinan elephant international trading co., LTD
- Tel
- 13006575422@163.com
Shanghai Chaolan Chemical Technology Center
- Tel
- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com
Amadis Chemical Company Limited
- Tel
- 571-89925085
- sales@amadischem.com