ZD 9379
ZD 9379 Basic information
- Product Name:
- ZD 9379
- Synonyms:
-
- ZD 9379
- 7-CHLORO-2,3-DIHYDRO-2-(4-METHOXY-2-METHYLPHENYL)PYRIDAZINO [4,5-B] QUINOLINE-1,4,10(5H)TRIONE
- Pyridazino[4,5-b]quinoline-1,4,10(5H)-trione, 7-chloro-2,3-dihydro-2-(4-methoxy-2-methylphenyl)-
- CAS:
- 170142-20-8
- MF:
- C19H14ClN3O4
- MW:
- 383.79
- Mol File:
- 170142-20-8.mol
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ZD 9379 Chemical Properties
- Density
- 1.54±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- <19.19mg/ml in DMSO; <7.68mg/ml in 1eq. NaOH
- pka
- 9.25±0.20(Predicted)
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ZD 9379 Usage And Synthesis
Uses
7-Chloro-2,3-dihydro-2-(4-methoxy-2-methylphenyl)pyridazino[4,5-b]quinoline-1,4,10(5H)-trione is a N-methyl-D-aspartate receptor antagonist and a neuroprotective agent.
in vivo
ZD-9379 (5 mg/kg) reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion[1].
| Animal Model: | Male Sprague-Dawley rats weighing 290 to 340 g undergoing permanent middle cerebral artery occlusion (MCAO)[1] |
| Dosage: | 5 mg/kg |
| Administration: | Group1: a 5-mg/kg bolus of ZD-9379 over 5 minutes followed by 5 mg/kg per hour drug infusion for 4 hours beginning 30 minutes before MCAO. Group 2: (post-MCAO treatment group), a 5-mg/kg bolus of ZD-9379 30 minutes after MCAO followed by 5 mg/kg per hour drug infusion for 4 hours. |
| Result: | Initiated before or after MCAO significantly reduced the number of Spreading depressions (SDs) and infarct volume in a permanent focal ischemia model. |
ZD 9379Supplier
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Jinan Yaoyan Pharmaceutical Co., Ltd.
- Tel
- jnyaoyan@163.com
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
- Tel
- meitaochem@126.com
- meitaochem@126.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
MedBioPharmaceutical Technology Inc
- Tel
- 021-69568360 18916172912
- order@med-bio.cn