3,4-Methylenedioxy-beta-nitrostyrene Chemical Properties

Melting point:

159-163 °C

Boiling point:

329.36°C (rough estimate)

Density 

1.4058 (rough estimate)

refractive index 

1.5200 (estimate)

storage temp. 

Sealed in dry,2-8°C

solubility 

Soluble in DMSO (up to 50 mg/ml).

form 

Yellow to brown solid

color 

Yellow

Sensitive 

Light Sensitive

BRN 

192350

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

InChI

InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2

InChIKey

KFLWBZPSJQPRDD-UHFFFAOYSA-N

SMILES

O1C2=CC=C(C=C[N+]([O-])=O)C=C2OC1

CAS DataBase Reference

1485-00-3(CAS DataBase Reference)

NIST Chemistry Reference

3,4-Methylenedioxy-«beta»-nitrostyrene(1485-00-3)

Safety Information

Hazard Codes 

Xn,Xi,T

Risk Statements 

36/37/38-22-25

Safety Statements 

36/37/39-26-45

RIDADR 

UN 2811 6.1/PG 3

RTECS 

WL5270000

HS Code 

29329990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

3,4-Methylenedioxy-beta-nitrostyrene Usage And Synthesis

Description

MDBN (1485-00-3) is an irreversible inhibitor of p97 (IC50 < 10 μM). Cell permeable.

Chemical Properties

yellow powder

Uses

MDBN is a Src and Syk kinase inhibitor that prevents phosphorylation and cytoskeletal association of GPIIb/IIIa and talin.

Biological Activity

Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC 50 = 12.7 μ M for thrombin-induced platelet aggregation). Exhibits no effects on Ca 2+ -dependent enzymes, PKC or arachidonic acid metabolism.

References

1) Chou et al. (2011), Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system; J. Biol. Chem., 286 16546

3,4-Methylenedioxy-beta-nitrostyrene(1485-00-3)Related Product Information

• Styrene
• 4-NITROSTYRENE
• 2,5-DIMETHOXY-BETA-NITROSTYRENE
• 1,2-Diphenylethylenediamine
• (E)-2-Nitroethenylbenzene
• 4-Nitrobenzonitrile
• 1,4-Dioxane
• Selenium dioxide
• TRANS-BETA-NITROSTYRENE
• 4-Nitrobenzoyl chloride
• 5-(2-NITROPROP-1-ENYL)-1,3-BENZODIOXOLE
• 3,4-Methylenedioxy-beta-nitrostyrene
• 1-(3,4-(METHYLENEDIOXY)-6-NITROPHENYL)-2-NITROETHENE
• 1-(6-BROMO-3,4-METHYLENEDIOXYPHENYL)-2-NITROETHENE
• 1-(6-BROMO-3,4-METHYLENEDIOXYPHENYL)-2-NITROPROPENE
• BETA-NITROISOMYRISTICIN
• 1-(3-METHOXY-4,5-METHYLENEDIOXYPHENYL)-2-NITROETHENE