3,4-Methylenedioxy-beta-nitrostyrene
3,4-Methylenedioxy-beta-nitrostyrene Basic information
- Product Name:
- 3,4-Methylenedioxy-beta-nitrostyrene
- Synonyms:
-
- 3,4-methylenedioxy-beta-nitro-styren
- 3,4-Methylenedioxy-omega-nitrostyrene
- 5-[(E)-2-Nitroethenyl]-1,3-benzodioxole
- 5-nitrovinyl-3-benzodioxole
- Benzene, 2-nitroethenyl, 3,4-methylenedioxy
- Ethene,-1-(3,4-methylendioxyphenyl)-2-nitro-
- Styrene, 3,4-methylenedioxy-beta-nitro-
- tyrene, 3,4-(methylenedioxy)-b-nitro-
- CAS:
- 1485-00-3
- MF:
- C9H7NO4
- MW:
- 193.16
- EINECS:
- 622-830-8
- Product Categories:
-
- Ethanes/ethenes
- Inhibitors
- Mol File:
- 1485-00-3.mol
3,4-Methylenedioxy-beta-nitrostyrene Chemical Properties
- Melting point:
- 159-163 °C
- Boiling point:
- 329.36°C (rough estimate)
- Density
- 1.4058 (rough estimate)
- refractive index
- 1.5200 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Soluble in DMSO (up to 50 mg/ml).
- form
- Yellow to brown solid
- color
- Yellow
- Sensitive
- Light Sensitive
- BRN
- 192350
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
- InChI
- InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2
- InChIKey
- KFLWBZPSJQPRDD-UHFFFAOYSA-N
- SMILES
- O1C2=CC=C(C=C[N+]([O-])=O)C=C2OC1
- CAS DataBase Reference
- 1485-00-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 3,4-Methylenedioxy-«beta»-nitrostyrene(1485-00-3)
Safety Information
- Hazard Codes
- Xn,Xi,T
- Risk Statements
- 36/37/38-22-25
- Safety Statements
- 36/37/39-26-45
- RIDADR
- UN 2811 6.1/PG 3
- RTECS
- WL5270000
- HS Code
- 29329990
3,4-Methylenedioxy-beta-nitrostyrene Usage And Synthesis
Description
MDBN (1485-00-3) is an irreversible inhibitor of p97 (IC50 < 10 μM). Cell permeable.
Chemical Properties
yellow powder
Uses
MDBN is a Src and Syk kinase inhibitor that prevents phosphorylation and cytoskeletal association of GPIIb/IIIa and talin.
Biological Activity
Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC 50 = 12.7 μ M for thrombin-induced platelet aggregation). Exhibits no effects on Ca 2+ -dependent enzymes, PKC or arachidonic acid metabolism.
in vivo
MNS (20 mg/kg, i.p.) ameliorates experimental burn wound progression in Wistar rats by inhibiting the NLRP3 inflammasome activation[7].
MNS (30 mg/kg, p.o., 5 days) alleviates DSS-induced mouse colitis by inhibiting the NLRP3 inflammasome[8].
MNS (20?mg/kg, i.p., 30?min before reperfusion) significantly protects the kidneys from RIR injury in rats by reducing PANoptosis through specific inhibition of NLRP3[9].
IC 50
NLRP3 inflammasome
References
[1] TSUI-FEN CHOU R J D. Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system.[J]. The Journal of Biological Chemistry, 2011, 286 19: 16546-16554. DOI:10.1074/jbc.m110.215319
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3,4-Methylenedioxy-beta-nitrostyrene(1485-00-3)Related Product Information
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- 4-NITROSTYRENE
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- (E)-2-Nitroethenylbenzene
- 4-Nitrobenzonitrile
- 1,4-Dioxane
- Selenium dioxide
- TRANS-BETA-NITROSTYRENE
- 4-Nitrobenzoyl chloride
- 5-(2-NITROPROP-1-ENYL)-1,3-BENZODIOXOLE
- 3,4-Methylenedioxy-beta-nitrostyrene
- 1-(3,4-(METHYLENEDIOXY)-6-NITROPHENYL)-2-NITROETHENE
- 1-(6-BROMO-3,4-METHYLENEDIOXYPHENYL)-2-NITROETHENE
- 1-(6-BROMO-3,4-METHYLENEDIOXYPHENYL)-2-NITROPROPENE
- BETA-NITROISOMYRISTICIN
- 1-(3-METHOXY-4,5-METHYLENEDIOXYPHENYL)-2-NITROETHENE