ChemicalBook > CAS DataBase List > 3,4-Methylenedioxy-beta-nitrostyrene

3,4-Methylenedioxy-beta-nitrostyrene

Product Name
3,4-Methylenedioxy-beta-nitrostyrene
CAS No.
1485-00-3
Chemical Name
3,4-Methylenedioxy-beta-nitrostyrene
Synonyms
MDBN;NSC 170724;MNS (MDBN);5-(2-Nitrovinyl);AKOS BBS-00006781;Syk Inhibitor III;TIMTEC-BB SBB007833;-nitrostyrene, MDBN);MNS (NSC 170724, MDBN);5-nitrovinyl-3-benzodioxole
CBNumber
CB8314918
Molecular Formula
C9H7NO4
Formula Weight
193.16
MOL File
1485-00-3.mol
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3,4-Methylenedioxy-beta-nitrostyrene Property

Melting point:
159-163 °C
Boiling point:
329.36°C (rough estimate)
Density 
1.4058 (rough estimate)
refractive index 
1.5200 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
Soluble in DMSO (up to 50 mg/ml).
form 
Yellow to brown solid
color 
Yellow
Sensitive 
Light Sensitive
BRN 
192350
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI
InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2
InChIKey
KFLWBZPSJQPRDD-UHFFFAOYSA-N
SMILES
O1C2=CC=C(C=C[N+]([O-])=O)C=C2OC1
CAS DataBase Reference
1485-00-3(CAS DataBase Reference)
NIST Chemistry Reference
3,4-Methylenedioxy-«beta»-nitrostyrene(1485-00-3)
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Safety

Hazard Codes 
Xn,Xi,T
Risk Statements 
36/37/38-22-25
Safety Statements 
36/37/39-26-45
RIDADR 
UN 2811 6.1/PG 3
RTECS 
WL5270000
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S352918
Product name
3,4-METHYLENEDIOXY-BETA-NITROSTYRENE
Purity
Aldrich
Packaging
250mg
Price
$179
Updated
2024/03/01
Sigma-Aldrich
Product number
574713
Product name
Syk Inhibitor III
Packaging
50mg
Price
$172
Updated
2024/03/01
Alfa Aesar
Product number
L09139
Product name
3,4-Methylenedioxy-beta-nitrostyrene, 98%
Packaging
10g
Price
$65.7
Updated
2021/12/16
Alfa Aesar
Product number
L09139
Product name
3,4-Methylenedioxy-beta-nitrostyrene, 98%
Packaging
50g
Price
$251
Updated
2021/12/16
Cayman Chemical
Product number
15206
Product name
MNS
Purity
≥95%
Packaging
10mg
Price
$48
Updated
2024/03/01
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3,4-Methylenedioxy-beta-nitrostyrene Chemical Properties,Usage,Production

Description

MDBN (1485-00-3) is an irreversible inhibitor of p97 (IC50 < 10 μM). Cell permeable.

Chemical Properties

yellow powder

Uses

MDBN is a Src and Syk kinase inhibitor that prevents phosphorylation and cytoskeletal association of GPIIb/IIIa and talin.

Biological Activity

Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC 50 = 12.7 μ M for thrombin-induced platelet aggregation). Exhibits no effects on Ca 2+ -dependent enzymes, PKC or arachidonic acid metabolism.

References

1) Chou et al. (2011), Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system; J. Biol. Chem., 286 16546

3,4-Methylenedioxy-beta-nitrostyrene Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Methylenedioxy-beta-nitrostyrene Suppliers

Shandong Xuanshuo Pharmaceutical Technology Co. LTD
Tel
15269103900
Email
suchangzhou@shiningpharm.com
Country
China
ProdList
265
Advantage
58
Suzhou Chukai PharmaTech
Tel
0512-88812066
Fax
86-512-63926099
Email
wenlongfcb@qq.com
Country
China
ProdList
350
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
sales@zhiwe.net
Country
China
ProdList
627
Advantage
61
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
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View Lastest Price from 3,4-Methylenedioxy-beta-nitrostyrene manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
3,4-Methylenedioxy-beta-nitrostyrene 1485-00-3
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-09-19
Shandong Hanjiang Chemical Co., Ltd
Product
3,4-Methylenedioxy-beta-nitrostyrene 1485-00-3
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10T
Release date
2024-01-15
Henan Bao Enluo International TradeCo.,LTD
Product
3,4-Methylenedioxy-beta-nitrostyrene 1485-00-3
Price
US $150.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000MT
Release date
2023-06-16

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