ChemicalBook > CAS DataBase List > 3,4-Methylenedioxy-beta-nitrostyrene

3,4-Methylenedioxy-beta-nitrostyrene

Product Name: 3,4-Methylenedioxy-beta-nitrostyrene
CAS No.: 1485-00-3
Chemical Name: 3,4-Methylenedioxy-beta-nitrostyrene
Synonyms: MDBN;NSC 170724;MNS (MDBN);5-(2-Nitrovinyl);AKOS BBS-00006781;Syk Inhibitor III;MNS, 10 mM in DMSO;TIMTEC-BB SBB007833;-nitrostyrene, MDBN);MNS (NSC 170724, MDBN)
CBNumber: CB8314918
Molecular Formula: C9H7NO4
Formula Weight: 193.16
MOL File: 1485-00-3.mol

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3,4-Methylenedioxy-beta-nitrostyrene Property

Melting point:: 159-163 °C
Boiling point:: 329.36°C (rough estimate)
Density: 1.4058 (rough estimate)
refractive index: 1.5200 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in DMSO (up to 50 mg/ml).
form: Yellow to brown solid
color: Yellow
Sensitive: Light Sensitive
BRN: 192350
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI: InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2
InChIKey: KFLWBZPSJQPRDD-UHFFFAOYSA-N
SMILES: O1C2=CC=C(C=C[N+]([O-])=O)C=C2OC1
CAS DataBase Reference: 1485-00-3(CAS DataBase Reference)
NIST Chemistry Reference: 3,4-Methylenedioxy-«beta»-nitrostyrene(1485-00-3)

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Safety

Hazard Codes: Xn,Xi,T
Risk Statements: 36/37/38-22-25
Safety Statements: 36/37/39-26-45
RIDADR: UN 2811 6.1/PG 3
RTECS: WL5270000
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S352918
Product name: 3,4-METHYLENEDIOXY-BETA-NITROSTYRENE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: 574713
Product name: Syk Inhibitor III
Packaging: 50mg
Price: $150
Updated: 2025/07/31

Sigma-Aldrich

Product number: S352918
Product name: 3,4-METHYLENEDIOXY-BETA-NITROSTYRENE
Purity: Aldrich
Packaging: 250mg
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: M3390
Product name: MNS
Purity: min. 98.0 %
Packaging: 100MG
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: M3390
Product name: MNS
Purity: min. 98.0 %
Packaging: 500MG
Price: $202
Updated: 2025/07/31

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3,4-Methylenedioxy-beta-nitrostyrene Chemical Properties,Usage,Production

Description

MDBN (1485-00-3) is an irreversible inhibitor of p97 (IC50 < 10 μM). Cell permeable.

Chemical Properties

yellow powder

Uses

MDBN is a Src and Syk kinase inhibitor that prevents phosphorylation and cytoskeletal association of GPIIb/IIIa and talin.

Biological Activity

Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC 50 = 12.7 μ M for thrombin-induced platelet aggregation). Exhibits no effects on Ca 2+ -dependent enzymes, PKC or arachidonic acid metabolism.

in vivo

MNS (20 mg/kg, i.p.) ameliorates experimental burn wound progression in Wistar rats by inhibiting the NLRP3 inflammasome activation^[7].
MNS (30 mg/kg, p.o., 5 days) alleviates DSS-induced mouse colitis by inhibiting the NLRP3 inflammasome^[8].
MNS (20?mg/kg, i.p., 30?min before reperfusion) significantly protects the kidneys from RIR injury in rats by reducing PANoptosis through specific inhibition of NLRP3^[9].

IC 50

NLRP3 inflammasome

References

[1] TSUI-FEN CHOU R J D. Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system.[J]. The Journal of Biological Chemistry, 2011, 286 19: 16546-16554. DOI:10.1074/jbc.m110.215319

3,4-Methylenedioxy-beta-nitrostyrene Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,4-Methylenedioxy-beta-nitrostyrene manufacturers

Shandong Hanjiang Chemical Co., Ltd

Product: 3,4-Methylenedioxy-beta-nitrostyrene 1485-00-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10T
Release date: 2024-01-15

Hebei Yanxi Chemical Co., Ltd.

Product: 3,4-Methylenedioxy-beta-nitrostyrene 1485-00-3
Price: US $50.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2023-09-19

Henan Bao Enluo International TradeCo.，LTD

Product: 3,4-Methylenedioxy-beta-nitrostyrene 1485-00-3
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000MT
Release date: 2023-06-16

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thrombin,aggregation,NSC170724,Inhibitor,Src,MNS,NSC 170724,activation,inhibit,NSC-170724,Spleen tyrosine kinase,derivative,GPIIb/IIIa,beta-nitrostyrene,Syk,platelet

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1485-00-3

Kinase/Phosphatase Biology

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