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3,4-Methylenedioxy-beta-nitrostyrene

Product Name
3,4-Methylenedioxy-beta-nitrostyrene
CAS No.
1485-00-3
Chemical Name
3,4-Methylenedioxy-beta-nitrostyrene
Synonyms
MDBN;NSC 170724;MNS (MDBN);5-(2-Nitrovinyl);AKOS BBS-00006781;Syk Inhibitor III;TIMTEC-BB SBB007833;-nitrostyrene, MDBN);MNS (NSC 170724, MDBN);5-nitrovinyl-3-benzodioxole
CBNumber
CB8314918
Molecular Formula
C9H7NO4
Formula Weight
193.16
MOL File
1485-00-3.mol
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3,4-Methylenedioxy-beta-nitrostyrene Property

Melting point:
159-163 °C
Boiling point:
329.36°C (rough estimate)
Density 
1.4058 (rough estimate)
refractive index 
1.5200 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
Soluble in DMSO (up to 50 mg/ml).
form 
Yellow to brown solid
color 
Yellow
Sensitive 
Light Sensitive
BRN 
192350
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI
InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2
InChIKey
KFLWBZPSJQPRDD-UHFFFAOYSA-N
SMILES
O1C2=CC=C(C=C[N+]([O-])=O)C=C2OC1
CAS DataBase Reference
1485-00-3(CAS DataBase Reference)
NIST Chemistry Reference
3,4-Methylenedioxy-«beta»-nitrostyrene(1485-00-3)
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Safety

Hazard Codes 
Xn,Xi,T
Risk Statements 
36/37/38-22-25
Safety Statements 
36/37/39-26-45
RIDADR 
UN 2811 6.1/PG 3
RTECS 
WL5270000
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S352918
Product name
3,4-METHYLENEDIOXY-BETA-NITROSTYRENE
Purity
Aldrich
Packaging
250mg
Price
$179
Updated
2024/03/01
Sigma-Aldrich
Product number
574713
Product name
Syk Inhibitor III
Packaging
50mg
Price
$172
Updated
2024/03/01
Alfa Aesar
Product number
L09139
Product name
3,4-Methylenedioxy-beta-nitrostyrene, 98%
Packaging
10g
Price
$65.7
Updated
2021/12/16
Alfa Aesar
Product number
L09139
Product name
3,4-Methylenedioxy-beta-nitrostyrene, 98%
Packaging
50g
Price
$251
Updated
2021/12/16
Cayman Chemical
Product number
15206
Product name
MNS
Purity
≥95%
Packaging
10mg
Price
$48
Updated
2024/03/01
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3,4-Methylenedioxy-beta-nitrostyrene Chemical Properties,Usage,Production

Description

MDBN (1485-00-3) is an irreversible inhibitor of p97 (IC50 < 10 μM). Cell permeable.

Chemical Properties

yellow powder

Uses

MDBN is a Src and Syk kinase inhibitor that prevents phosphorylation and cytoskeletal association of GPIIb/IIIa and talin.

Biological Activity

Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC 50 = 12.7 μ M for thrombin-induced platelet aggregation). Exhibits no effects on Ca 2+ -dependent enzymes, PKC or arachidonic acid metabolism.

References

1) Chou et al. (2011), Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system; J. Biol. Chem., 286 16546

3,4-Methylenedioxy-beta-nitrostyrene Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Methylenedioxy-beta-nitrostyrene Suppliers

Belgium 1 China 80 Germany 3 India 1 Sweden 2 Switzerland 3 Ukraine 1 United Kingdom 10 United States 25 Global 126
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View Lastest Price from 3,4-Methylenedioxy-beta-nitrostyrene manufacturers

Shandong Hanjiang Chemical Co., Ltd
Product
3,4-Methylenedioxy-beta-nitrostyrene 1485-00-3
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10T
Release date
2024-01-15
Hebei Yanxi Chemical Co., Ltd.
Product
3,4-Methylenedioxy-beta-nitrostyrene 1485-00-3
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-09-19
Henan Bao Enluo International TradeCo.，LTD
Product
3,4-Methylenedioxy-beta-nitrostyrene 1485-00-3
Price
US $150.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000MT
Release date
2023-06-16

1485-00-3, 3,4-Methylenedioxy-beta-nitrostyreneRelated Search:

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  • 3,4-methylenedioxy-beta-nitro-styren
  • 3,4-Methylenedioxy-omega-nitrostyrene
  • 5-[(E)-2-Nitroethenyl]-1,3-benzodioxole
  • 5-nitrovinyl-3-benzodioxole
  • Benzene, 2-nitroethenyl, 3,4-methylenedioxy
  • Ethene,-1-(3,4-methylendioxyphenyl)-2-nitro-
  • Styrene, 3,4-methylenedioxy-beta-nitro-
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  • AKOS BBS-00006781
  • 3,4-METHYLENEDIOXYNITROSTYRENE
  • 3,4-METHYLENEDIOXY-BETA-NITROSTYRENE
  • 3,4-METHYLENEDIOXY-B-NITROSTYRENE
  • 1-(3,4-METHYLENEDIOXYPHENYL) 2-NITROETHENE
  • TIMTEC-BB SBB007833
  • 4-Methylenedioxy-beta-nitrostyrene
  • Syk Inhibitor III - CAS 1485-00-3 - Calbiochem
  • 3,4-methylenedioxy-á-nitrostyrene
  • 3,4-METHYLENDIOXY-BETA-NITROSTYRENE
  • 3,4-METHYLENEDIOXY-SS-NITROSTYRENE
  • 1-(2-Nitrovinyl)-3,4-methylenedioxybenzene
  • 5-(2-Nitroethenyl)-1,3-benzodioxole
  • 5-(2-Nitrovinyl)-1,3-benzodioxole
  • -(2-Nitrovinyl)-1,3-benzodioxole
  • -(2-Nitrovinyl)-3,4-methylenedioxybenzene
  • ,4-(Methylenedioxy)-b-nitrostyrene
  • ,4-Methylenedioxy-1-(2-nitrovinyl)benzene
  • 1,3-Benzodioxole, 5-(2-nitroethenyl)-
  • 1,3-Benzodioxole, 5-nitrovinyl-
  • 5-(2-Nitrovinyl)
  • Syk Inhibitor III
  • 3,4-Methylenedioxy-beta-nitrostyrene,98%
  • (E)-5-(2-nitrovinyl)benzo[d][1,3]dioxole
  • MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)
  • MNS (3,4-Methylenedioxy-&beta
  • -nitrostyrene, MDBN)
  • 5-(2-Nitrovinyl)benzo[d][1,3]dioxole
  • MNS (3,4-Methylenedioxy-beta-nitrostyrene, MDBN)
  • MDBN
  • 5-(2-Nitrovinyl)benzodioxole
  • NSC 170724
  • 3,4-Methylenedioxy-β-nitrostyrene
  • MNS (MDBN)
  • MNS (NSC 170724, MDBN)
  • thrombin,aggregation,NSC170724,Inhibitor,Src,MNS,NSC 170724,activation,inhibit,NSC-170724,Spleen tyrosine kinase,derivative,GPIIb/IIIa,beta-nitrostyrene,Syk,platelet
  • MNS (3，4-Methylenedioxy-β-nitrostyrene， MDBN)
  • 1485-00-3
  • Kinase/Phosphatase Biology
  • Non-Receptor Tyrosine Kinase Inhibitors
  • Spleen Tyrosine Kinase (Syk)
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Ethanes/ethenes
  • Inhibitors