5-BROMO-2-CHLORO-4-PICOLINE Chemical Properties

Melting point:

25-30 °C

Boiling point:

239℃

Density 

1.624

refractive index 

1.5400 (estimate)

Flash point:

99℃

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to lump to clear liquid

pka

-1.45±0.10(Predicted)

color 

White or Colorless to Light yellow

InChI

InChI=1S/C6H5BrClN/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3

InChIKey

ISESOOISZHSENQ-UHFFFAOYSA-N

SMILES

C1(Cl)=NC=C(Br)C(C)=C1

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-41-22-37/38

Safety Statements 

37/39-26-39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29333990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1

MSDS

• Language:English Provider:ACROS

5-BROMO-2-CHLORO-4-PICOLINE Usage And Synthesis

Chemical Properties

Clear pale yellow low melting solid

Uses

5-Bromo-2-chloro-4-methylpyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

A solution of 2-chloro-5-bromopyridine (386 mg, 2 mmol) in THF (6 mL) was cooled to -78??C and tert-butyl bromide (1.17 mL, 2 mmmol) was added dropwise under nitrogen. After 5 min at -78??C, the brown solution was treated with a solution of the appropriate electrophilic reagent (3 mmol) in THF (4 mL). The reaction medium was then allowed to warm to room temperature (1 h) and the mixture was hydrolyzed with H2O (10 mL) at 0??C. The aqueous layer was then extracted with Et2O. The organic layer (MgSO4) was dried and the solvent was evaporated under reduced pressure. The crude product was purified by column chromatography. Eluent: hexane-ethyl acetate (90:10). Compound - Chloro-4-methyl-5-bromopyridine in 50% yield.

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