ChemicalBook > Product Catalog > Analytical Chemistry > Standard > Pharmaceutical Impurity Reference Standards > 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione
1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione
1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione Basic information
- Product Name:
- 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione
- Synonyms:
-
- 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione
- 5-Hydroxy-arabinouridine
- Cytarabine Impurity 17
- 1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-hydroxypyrimidine-2,4(1H,3H)-dione
- Cytarabine Impurity 28
- 2,4(1H,3H)-Pyrimidinedione, 1-β-D-arabinofuranosyl-5-hydroxy-
- Cytarabine 19
- CAS:
- 69321-95-5
- MF:
- C9H12N2O7
- MW:
- 260.20078
- Mol File:
- 69321-95-5.mol
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1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione Chemical Properties
- Density
- 1.848±0.06 g/cm3(Predicted)
- pka
- 8?+-.0.20(Predicted)
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1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione Usage And Synthesis
Uses
5-Hydroxy-arabinouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
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