(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid
(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid Basic information
- Product Name:
- (2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid
- Synonyms:
-
- (2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid
- Boc-Val-Cit-OH
- Boc-Val-Cit
- L-Ornithine, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-
- (R)-2-((R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-5-ureidopentanoic acid
- Boc-L-valyl-L-citrulline
- ADC Linkers,Inhibitor,Boc Val Cit OH,BocValCitOH,Antibody-drug conjugates linkers,inhibit
- N-Boc-L-valyl-N5-(aminocarbonyl)-L-ornithine
- CAS:
- 870487-08-4
- MF:
- C16H30N4O6
- MW:
- 374.43
- Product Categories:
-
- Linker
- ADC LINKER
- Mol File:
- 870487-08-4.mol
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(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid Chemical Properties
- Boiling point:
- 624.8±55.0 °C(Predicted)
- Density
- 1.183±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in DMSO
- pka
- 3.44±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- InChIKey
- ZZLNUAVYYRBTOZ-QWRGUYRKSA-N
- SMILES
- C(O)(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](C(C)C)NC(OC(C)(C)C)=O
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(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid Usage And Synthesis
Description
Boc-Val-Cit is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. Boc group can be removed under acidic condition.
Uses
Boc-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
IC 50
Protease Cleavable Linker; Cleavable Linker
References
[1] Kevin HAMBLETT, et al. Anti-her2 biparatopic antibody-drug conjugates and methods of use. WO2019173911A1.
(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acidSupplier
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