(S)-2-((S)-2-(tert-butoxycarbonylaMino)-3-MethylbutanaMido)propanoic acid
(S)-2-((S)-2-(tert-butoxycarbonylaMino)-3-MethylbutanaMido)propanoic acid Basic information
- Product Name:
- (S)-2-((S)-2-(tert-butoxycarbonylaMino)-3-MethylbutanaMido)propanoic acid
- Synonyms:
-
- (S)-2-((S)-2-(tert-butoxycarbonylaMino)-3-MethylbutanaMido)propanoic acid
- (Tert-Butoxy)Carbonyl Val-Ala-OH
- N-Boc-L-valyl- L-alanine
- (2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]propanoic acid
- (tert-Butoxycarbonyl)-L-valyl-L-alanine
- L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-
- Boc-Val-Ala
- Boc-L-Valyl- L-Alanin
- CAS:
- 70396-18-8
- MF:
- C13H24N2O5
- MW:
- 288.34
- Mol File:
- 70396-18-8.mol
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(S)-2-((S)-2-(tert-butoxycarbonylaMino)-3-MethylbutanaMido)propanoic acid Chemical Properties
- Boiling point:
- 493.3±30.0 °C(Predicted)
- Density
- 1.121±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.50±0.10(Predicted)
- form
- Solid
- color
- White to off-white
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(S)-2-((S)-2-(tert-butoxycarbonylaMino)-3-MethylbutanaMido)propanoic acid Usage And Synthesis
Description
Boc-Val-Ala-OH is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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