2-Bromo-5-methoxybenzaldehyde Chemical Properties

Melting point:

71-76 °C

Boiling point:

284.3±20.0 °C(Predicted)

Density 

1.522±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Acetonitrile (Slightly), Chloroform (Slightly)

form 

Solid

color 

White to Off-White

InChI

InChI=1S/C8H7BrO2/c1-11-7-2-3-8(9)6(4-7)5-10/h2-5H,1H3

InChIKey

XNHKTMIWQCNZST-UHFFFAOYSA-N

SMILES

C(=O)C1=CC(OC)=CC=C1Br

CAS DataBase Reference

7507-86-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2913000090

2-Bromo-5-methoxybenzaldehyde Usage And Synthesis

Chemical Properties

White powder

Uses

2-Bromo-5-methoxybenzaldehyde is used in preparation of Benzimidazole Quinolines. Also, used in preparation of Cyclopentenes, Polycycles, Benzocarbocycles/N-Heterocycle derivatives.

Synthesis

3-Methoxybenzaldehyde (6.06 g, 44.6 mmol, 1.0 eq.) was used as a starting material, which was dissolved in acetic acid (10 mL), followed by slow dropwise addition of bromine (2.75 mL, 53.6 mmol, 1.2 eq.). The reaction mixture was stirred at 25°C for 36 hours. Upon completion of the reaction, the reaction was quenched with saturated sodium sulfite solution (50 mL), the mixture was poured into water (20 mL) and extracted with ether (5 x 30 mL). The organic layers were combined, washed sequentially with water (3 x 25 mL) and brine (30 mL), dried over anhydrous magnesium sulfate and concentrated to give the target product 2-bromo-5-methoxybenzaldehyde (9.49 g, 99% yield) as a dark yellow solid. Alternatively, the aldehyde was commercially available. Next, 2-bromo-5-methoxybenzaldehyde (9.49 g, 44.2 mmol, 1.0 eq.) was dissolved in acetonitrile (200 mL), and this solution was added to stirring phosphonate (14.9 g, 44.2 mmol, 1.0 eq.), lithium chloride (2.44 g, 57.4 mmol, 1.3 eq.), and 1,8-diazabicyclo[5.4. 0]undec-7-ene (DBU, 6.59 mL, 44.2 mmol, 1.0 equiv) in a mixture. The resulting dark yellow solution was stirred at 25°C for 12 hours. Upon completion of the reaction, the reaction was quenched by addition of saturated ammonium chloride solution (100 mL) and concentrated to remove the organic solvent. The residue was redissolved in ethyl acetate (50 mL), poured into water (50 mL) and extracted with ethyl acetate (3 x 50 mL). The organic extracts were combined, washed sequentially with water (50 mL) and brine (50 mL), dried over anhydrous magnesium sulfate and concentrated to give the diester product (17.5 g, 99% yield) as a yellow oil. The product was characterized as follows: rf = 0.57 (silica gel plate, hexane/ethyl acetate, 4:1); IR (thin film) 2979, 2936, 1724, 1643, 1590, 1569, 1465, 1285, 1238, 1194, 1156, 1097, 1019 cm^-1; ^1H NMR (400 MHz, CDCl3) δ 7.80 (s, 1H), 7.47 (d, J = 8.8 Hz, 1H), 6.94 (d, J = 2.8 Hz, 1H), 6.77 (dd, J = 8.8, 2.8 Hz, 1H), 4.29 (q, J = 7.2 Hz, 2H), 3.76 (s, 3H), 3.33 (s, 2H), 1.45 (s, 9H), 1.35 (t, J = 7.2 Hz, 3H); ^13C NMR (75 MHz, CDCl3) δ 170.2, 166.9, 158.7, 140.6, 136.3, 133.3, 128.3, 116.5, 115.0, 114.3, 81.1, 61.2, 55.5, 35.2, 28.0, 14.2; HRMS (MALDI-FTMS) calculated value C18H23BrO5 [M+] 398.0729, measured value 398.0746.

References

[1] Angewandte Chemie - International Edition, 2010, vol. 49, # 30, p. 5146 - 5150
[2] Patent: WO2011/103442, 2011, A2. Location in patent: Page/Page column 62-63
[3] Patent: KR2015/107357, 2015, A. Location in patent: Paragraph 0063-0065
[4] Tetrahedron Letters, 2010, vol. 51, # 10, p. 1383 - 1385
[5] Heterocycles, 1986, vol. 24, # 2, p. 297 - 302

2-Bromo-5-methoxybenzaldehyde(7507-86-0)Related Product Information

• o-Anisaldehyde
• 2,5-Dimethoxybenzaldehyde
• 2-Nitrobenzaldehyde
• 4-Hydroxybenzaldehyde
• 3,5-Dimethoxybenzaldehyde
• 2,3-Dimethoxybenzaldehyde
• 4-Dimethylaminobenzaldehyde
• 2,4-Dimethoxybenzaldehyde
• Anisole
• 3-Methoxybenzaldehyde
• 2,6-Dimethoxybenzaldehyde
• (Trifluoromethoxy)benzene
• Veratraldehyde
• 3-(METHOXYMETHOXY)BENZALDEHYDE
• p-Anisaldehyde
• Benzaldehyde
• 2-BROMO-5-METHOXYBENZOIC ACID
• 2-Methoxyethanol