Fusidine Chemical Properties

Melting point:

190-192°C

Boiling point:

521.49°C (rough estimate)

alpha 

D20 -9° (chloroform)

Density 

1.0389 (rough estimate)

vapor pressure 

0-0Pa at 25℃

refractive index 

1.4890 (estimate)

storage temp. 

Sealed in dry,2-8°C

solubility 

Practically insoluble in water, freely soluble in ethanol (96 per cent)

pka

pK: 5.35 in water

form 

Solid

color 

White to Off-White

optical activity

-920 (c 1, CHCl3)

Water Solubility 

2.376-525000μg/L at 25℃

λmax

204nm(H2O)(lit.)

Merck 

14,4317

Stability:

Hygroscopic

LogP

2.68-6.75 at 20℃

CAS DataBase Reference

6990-06-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

WGK Germany 

3

RTECS 

RC1350000

HS Code 

29419000

Toxicity

LD50 in mice (g/kg): 1.2 s.c.; 1.5 orally (Godtfredsen)

MSDS

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Fusidine Usage And Synthesis

Mode of action

Fusidic acid forms a stable complex with an elongation factor (EF-G) involved in translocation and with guanosine triphosphate (GTP), which provides energy for the translocation process. One round of translocation occurs, with hydrolysis of GTP, but the fusidic acid–EF-G–GDP complex cannot dissociate from the ribosome, thereby blocking further chain elongation and leaving peptidyl-tRNA in the P site.
Although protein synthesis in Gram-negative bacilli–and, indeed, mammalian cells–is susceptible to fusidic acid, the antibiotic penetrates poorly into these cells and the spectrum of action is virtually restricted to Gram-positive bacteria, notably staphylococci.

Description

Fusidic acid was found in the culture broth of a fungus imperfectus, Fusidium coccineum, by Leo in 1962. It has a steroid struc ture but shows no hormonal activity.

Chemical Properties

White Solid

Uses

antibacterial

Uses

Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Dyes and metabolites.

Definition

ChEBI: A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.

brand name

Fucidine (Bristol-Myers Squibb).

Hazard

Moderately toxic inhibitor of translocation during protein synthesis.

Biological Activity

Fusidic acid shows very strong activity against Staphy lococcus aureus and weak activity against other gram-positive bacteria and gram-negative cocci and Mycobacterium.

Biochem/physiol Actions

Fusidic acid is a tetracyclic triterpenoid with antibiotic activity against Gram-positive bacteria. It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections.

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