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N-ACETYLPROCAINAMIDE

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N-ACETYLPROCAINAMIDE Basic information

Product Name:
N-ACETYLPROCAINAMIDE
Synonyms:
  • 4-(acetylamino)-n-(2-(diethylamino)ethyl)-benzamid
  • 4-(acetylamino)-n-[2-(diethylamino)ethyl]-benzamid
  • 4-acetamido-N-(2-(diethylamino)ethyl)benzamide
  • 4’-((2-(diethylamino)ethyl)carbamoyl)-acetanilid
  • 4’-((2-(diethylamino)ethyl)carbamoyl)acetanilide
  • acecainide
  • acekainid
  • n-acetyloprokainamid
CAS:
32795-44-1
MF:
C15H23N3O2
MW:
277.36
Product Categories:
  • TINDAMAX
  • Amides
  • Carbonyl Compounds
  • Organic Building Blocks
Mol File:
32795-44-1.mol
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N-ACETYLPROCAINAMIDE Chemical Properties

Melting point:
138-140 °C(lit.)
Boiling point:
500.0±35.0 °C(Predicted)
Density 
1.097±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
soluble1%, clear, colorless to faintly yellow (1N HCl)
form 
Solid
pka
14.54±0.46(Predicted)
color 
White to off-white
Merck 
13,20
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
3249
WGK Germany 
3
RTECS 
AE1974350
HazardClass 
6.1(b)
PackingGroup 
III

MSDS

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N-ACETYLPROCAINAMIDE Usage And Synthesis

Originator

Acecainide ,ZYF Pharm Chemical

Uses

antiprotozoal

Uses

N-acetylprocainamide (NAPA) was used as a model drug in the study of establishing a quantitative approach to predict the renal clearances of basic drugs using N-1-methylnicotinamide (NMN).

Definition

ChEBI: A benzamide obtained via formal condensation of 4-acetamidobenzoic acid and 2-(diethylamino)ethylamine.

Manufacturing Process

1.0 g of p-amino-N-(2-diethylaminoethyl)benzamide is dissolved in chloroform. A few ice cubes are added to the solution. Acetyl chloride is added dropwise with stirring until no more white precipitate forms; the latter is separated by filtering under suction. The precipitate is washed with cold acetone and dried overnight in a vacuum oven at room temperature. The product is dissolved in a minimum amount of hot isopropanol and allowed to precipitate in the cold. The p-acetamido-N-(2-diethylaminoethyl)benzamide hydrochloride, is recrystallized a second time from hot isopropanol, melting point 190°-193°C. The free base is obtained from the hydrochloride by dissolving the latter in water, adjusting the pH to greater than 10 with dilute sodium hydroxide, and adding an equal volume of benzene. After shaking in a separatory funnel, the benzene layer is recovered and evaporated to dryness. So the p-acetamido-N- (2-diethylaminoethyl)benzamide is obtained.

Therapeutic Function

Antiarrhythmic

General Description

The relaxant effects of N-acetylprocainamide on bovine tracheal smooth muscle was studied.

N-ACETYLPROCAINAMIDESupplier

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