N-ACETYLPROCAINAMIDE
- Product Name
- N-ACETYLPROCAINAMIDE
- CAS No.
- 32795-44-1
- Chemical Name
- N-ACETYLPROCAINAMIDE
- Synonyms
- acekainid;acecainide;TIMTEC-BB SBB005970;N-ACETYLPROCAINAMIDE;n-acetyloprokainamid;N-ACETYLPROCAINAMIDE, 99+%;N-ACETYLPROCAINAMIDE USP/EP/BP;4-acetamido-N-(2-(diethylamino)ethyl)benzamide;4’-((2-(diethylamino)ethyl)carbamoyl)acetanilide;4’-((2-(diethylamino)ethyl)carbamoyl)-acetanilid
- CBNumber
- CB8432449
- Molecular Formula
- C15H23N3O2
- Formula Weight
- 277.36
- MOL File
- 32795-44-1.mol
N-ACETYLPROCAINAMIDE Property
- Melting point:
- 138-140 °C(lit.)
- Boiling point:
- 500.0±35.0 °C(Predicted)
- Density
- 1.097±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- soluble1%, clear, colorless to faintly yellow (1N HCl)
- form
- Solid
- pka
- 14.54±0.46(Predicted)
- color
- White to off-white
- Merck
- 13,20
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 269476
- Product name
- N-Acetylprocainamide
- Purity
- ≥99%
- Packaging
- 250mg
- Price
- $62.4
- Updated
- 2024/03/01
- Product number
- 269476
- Product name
- N-Acetylprocainamide
- Purity
- ≥99%
- Packaging
- 1g
- Price
- $176
- Updated
- 2024/03/01
- Product number
- CHM0031256
- Product name
- N-ACETYLPROCAINAMIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $681.09
- Updated
- 2021/12/16
- Product number
- CS-4707
- Product name
- N-Acetylprocainamide
- Purity
- ≥98.0%
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CSN11506
- Product name
- N-Acetylprocainamide
- Packaging
- 100mg
- Price
- $48
- Updated
- 2021/12/16
N-ACETYLPROCAINAMIDE Chemical Properties,Usage,Production
Originator
Acecainide ,ZYF Pharm Chemical
Uses
antiprotozoal
Uses
N-acetylprocainamide (NAPA) was used as a model drug in the study of establishing a quantitative approach to predict the renal clearances of basic drugs using N-1-methylnicotinamide (NMN).
Definition
ChEBI: A benzamide obtained via formal condensation of 4-acetamidobenzoic acid and 2-(diethylamino)ethylamine.
Manufacturing Process
1.0 g of p-amino-N-(2-diethylaminoethyl)benzamide is dissolved in
chloroform. A few ice cubes are added to the solution. Acetyl chloride is added
dropwise with stirring until no more white precipitate forms; the latter is
separated by filtering under suction. The precipitate is washed with cold
acetone and dried overnight in a vacuum oven at room temperature. The
product is dissolved in a minimum amount of hot isopropanol and allowed to
precipitate in the cold. The p-acetamido-N-(2-diethylaminoethyl)benzamide
hydrochloride, is recrystallized a second time from hot isopropanol, melting
point 190°-193°C.
The free base is obtained from the hydrochloride by dissolving the latter in
water, adjusting the pH to greater than 10 with dilute sodium hydroxide, and
adding an equal volume of benzene. After shaking in a separatory funnel, the
benzene layer is recovered and evaporated to dryness. So the p-acetamido-N-
(2-diethylaminoethyl)benzamide is obtained.
Therapeutic Function
Antiarrhythmic
General Description
The relaxant effects of N-acetylprocainamide on bovine tracheal smooth muscle was studied.
N-ACETYLPROCAINAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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