Cloxacepride

Product Name: Cloxacepride
CAS No.: 65569-29-1
Chemical Name: Cloxacepride
Synonyms: Cloxacepride;5-Chloro-4-[(4-chlorophenoxy)acetylamino]-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;5-Chloro-4-[[(4-chlorophenoxy)acetyl]amino]-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;Benzamide, 5-chloro-4-[[2-(4-chlorophenoxy)acetyl]amino]-N-[2-(diethylamino)ethyl]-2-methoxy-
CBNumber: CB81116106
Molecular Formula: C22H27Cl2N3O4
Formula Weight: 468.37
MOL File: 65569-29-1.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0011131
Product name: CLOXACEPRIDE
Purity: 95.00%
Packaging: 5MG
Price: $503.15
Updated: 2021/12/16

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Cloxacepride Chemical Properties,Usage,Production

Uses

Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity[1][2].

in vivo

Oral ED₅₀ values for cloxacepride of 46-49 mg/kg were comparable to that of theophylline (HY-B0809) and to an intravenous injection of 2 mg/kg of disodium chromoglycate (DSCG) followed by immediate challenge^[1].
Cloxacepride has anti-PCA activity when administered orally 15 or 60 min before antigenic challenge^[1].

References

[1] Metz G, et al. Cloxacepride and related compounds: a new series of orally active antiallergic compounds. J Med Chem. 1983 Jul;26(7):1065-70. DOI:10.1021/jm00361a022
[2] Gigl G, et al. Calmodulin antagonism: a pharmacological approach for the inhibition of mediator release from mast cells. Cell Calcium. 1987 Oct;8(5):327-44. DOI:10.1016/0143-4160(87)90008-x
[3] Friedrich G, et al. Inhibitory effect of cloxacepride on compound 48/80-induced histamine and serotonin release from rat mast cells. Arch Int Pharmacodyn Ther. 1984 Feb;267(2):264-8. PMID:6201147

Cloxacepride Preparation Products And Raw materials

Raw materials

Preparation Products

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Cloxacepride Suppliers

China 6 United States 2 Global 8

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29496
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

65569-29-1, CloxaceprideRelated Search:

Metoclopramide hydrochloride Metoclopramide monohydrochloride monohydrate N-ACETYLPROCAINAMIDE Procainamide hydrochloride 2'-Chloro-4'-methylacetanilide 2-Chloro-5-methoxyaniline Declopramide 5-[(2-Hydroxyethyl)amino]-o-cresol N-{4-[(methylamino)methyl]phenyl}acetamide N-ACETYLPROCAINAMIDE HYDROCHLORIDE 5-Amino-4-chloro-2-methylphenol Cloxacepride

Cloxacepride

5-Chloro-4-[(4-chlorophenoxy)acetylamino]-N-[2-(diethylamino)ethyl]-2-methoxybenzamide

5-Chloro-4-[[(4-chlorophenoxy)acetyl]amino]-N-[2-(diethylamino)ethyl]-2-methoxybenzamide

Benzamide, 5-chloro-4-[[2-(4-chlorophenoxy)acetyl]amino]-N-[2-(diethylamino)ethyl]-2-methoxy-

65569-29-1

C22H27Cl2N3O4