4-Aminobenzohydrazide Chemical Properties

Melting point:

225-227 °C (lit.)

Boiling point:

273.17°C (rough estimate)

Density 

1.2100 (rough estimate)

refractive index 

1.5860 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMF: 10 mg/ml; DMSO: 14 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml

pka

13.05±0.10(Predicted)

form 

Crystals or Powder

color 

White or beige

Water Solubility 

Soluble in DMSO (10 mg/ml), dilute acids, and water (partly miscible).

BRN 

639053

CAS DataBase Reference

5351-17-7(CAS DataBase Reference)

NIST Chemistry Reference

Benzoic acid, 4-amino-, hydrazide(5351-17-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

DG2580000

HazardClass 

IRRITANT

HS Code 

29280000

MSDS

• Language:English Provider:(4-Aminobenzoyl)hydrazide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Aminobenzohydrazide Usage And Synthesis

Description

4-Aminobenzoic acid hydrazide (4-ABAH) is an irreversible inhibitor of myeloperoxidase (MPO; IC₅₀ = 0.3 μM). It reduces the production of hypochlorous acid (HOCl) induced by opsonized zymosan or phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils with IC₅₀ values of 16 and 2.2 μM, respectively. 4-ABAH inhibits PMA-induced formation of neutrophil extracellular traps (NETs) in the same cells. It reduces infarct volume and the severity of neurological deficits, as well as increases survival, in a mouse model of cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO) when administered at a dose of 40 mg/kg twice per day.

Chemical Properties

White or beige crystals or powder

Uses

4-Aminobenzhydrazide has an important role in the peroxidation activity of MPO. It is also used in enzyme preparations and in cell cultures.

Uses

4-Aminobenzoic hydrazide can be used as a reactant to synthesize:

• Acylhydrazone Schiff base ligand by condensation reaction with 2-acetylpyridine.
• Oligomeric transition metal complexes applicable in the fabrication of organic-inorganic hybrid devices with efficient electrical and photoelectrical properties.
• Oxovanadium(IV)-hydrazide complex as a potential radical scavenger.

4-Aminobenzohydrazide(5351-17-7)Related Product Information

• Carbohydrazide
• Formylhydrazine
• Phthalhydrazide
• 1,5-Diphenylcarbazide
• Tebufenozide
• Adipic dihydrazide
• p-Aminobenzamide
• 1,2-Diformylhydrazine
• Daminozide
• Benzoyl hydrazine
• P-AMINOBENZAMIDE GLUTAMIC ACID
• 4-Hydroxybenzhydrazide
• Anthranilamide
• 4-Aminobenzoic acid
• METHOXYFENOZIDE
• Maleic hydrazide
• antioxidant 1024
• 4-DIMETHYLAMINOBENZHYDRAZIDE