5-CHLORO INDAZOLE-3-CARBOXALDEHYDE Chemical Properties

Boiling point:

391.7±22.0 °C(Predicted)

Density 

1.521±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

10.85±0.40(Predicted)

form 

solid

color 

Brown

Safety Information

HS Code 

29339900

5-CHLORO INDAZOLE-3-CARBOXALDEHYDE Usage And Synthesis

Chemical Properties

Light yellow solid

Synthesis

Step 3: Manganese dioxide (0.991 g, 11.4 mmol) was added to a solution of (5-chloro-1H-indazol-3-yl)methanol (0.208 g, 1.14 mmol) in ethyl acetate (10 mL) at room temperature. The reaction mixture was stirred overnight. Subsequently, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated. The resulting residue was purified by silica gel column chromatography (eluent: chloroform/methanol) to afford the target product 5-chloro-1H-indazole-3-carbaldehyde (0.106 g, 51% yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 7.53 (dd, J = 2.2,8.8 Hz, 1H), 7.77 (d, J = 8.8 Hz, 1H), 8.11 (d, J = 2.2 Hz, 1H), 10.18 (s, 1H), 14.36 (br s, 1H).

References

[1] Journal of the American Chemical Society, 1986, vol. 108, # 14, p. 4115 - 4119
[2] Patent: EP2565192, 2013, A1. Location in patent: Paragraph 0359

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