N3-PEG10-N3 CAS#: 1171122-72-7

N3-PEG10-N3 Basic information

Product Name:

N3-PEG10-N3

Synonyms:

N3-PEG10-N3
1,29-diazido-3,6,9,12,15,18,21,24,27-nonaoxanonacosane
Inhibitor,inhibit,PROTAC Linkers,AzidoPEG9azide,Azido PEG9 azide,Azido-PEG-9-azide
Azide-PEG9-azide
Azido-PEG9-azid
N3-PEG9-CH2CH2N3

CAS:

1171122-72-7

MF:

C20H40N6O9

MW:

508.57

Mol File:

1171122-72-7.mol

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N3-PEG10-N3 Usage And Synthesis

Uses

Azido-PEG9-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG9-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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