H2N-PEG11-CH2CH2COOH
H2N-PEG11-CH2CH2COOH Basic information
- Product Name:
- H2N-PEG11-CH2CH2COOH
- Synonyms:
-
- H2N-PEG11-CH2CH2COOH
- Amino-PEG11-propionic acid
- Amino-PEG11-COOH
- Amino-PEG11-acid
- H2N-PEG11-CH2CH2COOH/4,7,10,13,16,19,22,25,28,31,34-Undecaoxahexatriacontanoic acid, 36 amino-
- 4,7,10,13,16,19,22,25,28,31,34-Undecaoxahexatriacontanoic acid, 36 amino-
- CAS:
- 1616426-12-0
- MF:
- C25H51NO13
- MW:
- 573.67
- Mol File:
- 1616426-12-0.mol
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H2N-PEG11-CH2CH2COOH Chemical Properties
- Boiling point:
- 637.6±55.0 °C(Predicted)
- Density
- 1.125±0.06 g/cm3(Predicted)
- pka
- 4.28±0.10(Predicted)
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H2N-PEG11-CH2CH2COOH Usage And Synthesis
Biological Activity
Amino-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
H2N-PEG11-CH2CH2COOHSupplier
T&W GROUP
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Xi'an Confluore Biological Technology Co., Ltd.
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SHANGHAI T&W PHARMACEUTICAL CO., LTD.
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H2N-PEG11-CH2CH2COOH(1616426-12-0)Related Product Information
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