H2N-PEG11-CH2CH2COOH CAS#: 1616426-12-0

H2N-PEG11-CH2CH2COOH Basic information

Product Name:

H2N-PEG11-CH2CH2COOH

Synonyms:

H2N-PEG11-CH2CH2COOH
Amino-PEG11-propionic acid
Amino-PEG11-COOH
Amino-PEG11-acid
H2N-PEG11-CH2CH2COOH/4,7,10,13,16,19,22,25,28,31,34-Undecaoxahexatriacontanoic acid, 36 amino-
4,7,10,13,16,19,22,25,28,31,34-Undecaoxahexatriacontanoic acid, 36 amino-

CAS:

1616426-12-0

MF:

C25H51NO13

MW:

573.67

Mol File:

1616426-12-0.mol

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H2N-PEG11-CH2CH2COOH Chemical Properties

Boiling point:: 637.6±55.0 °C(Predicted)
Density: 1.125±0.06 g/cm3(Predicted)
pka: 4.28±0.10(Predicted)

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H2N-PEG11-CH2CH2COOH Usage And Synthesis

Biological Activity

Amino-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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