ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > Telratolimod
Telratolimod
Telratolimod Basic information
- Product Name:
- Telratolimod
- Synonyms:
-
- Telratolimod
- Octadecanamide, N-[4-[(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)oxy]butyl]-
- 3M-052
- MEDI9197
- N-(4-((4-Amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)oxy)butyl)stearamide
- Toll-like Receptor (TLR),MEDI-9197,inhibit,Inhibitor,Telratolimod,MEDI 9197
- N-[4-(4-amino-2-butyl-imidazo[4,5-c]quinolin-1-yl)oxybutyl]octadecanamide
- Telratolimod, 10 mM in DMSO
- CAS:
- 1359993-59-1
- MF:
- C36H59N5O2
- MW:
- 593.89
- Mol File:
- 1359993-59-1.mol
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Telratolimod Chemical Properties
- Density
- 1.08±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: slightly soluble; Ethanol: slightly soluble
- form
- A crystalline solid
- pka
- 16.28±0.46(Predicted)
- color
- White to light yellow
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Telratolimod Usage And Synthesis
Uses
Telratolimod (MEDI9197) is a potent toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity[1].
in vivo
Telratolimod (50 μg) inhibits the tumor volume, and more potently blocks tumor gowth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs survival of mice bearing large tumors[1].
IC 50
TLR7; TLR8
References
[1] Zhao BG, et al. Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors. J Immunother Cancer. 2014 May 13;2:12. DOI:10.1186/2051-1426-2-12
TelratolimodSupplier
Shanghai Raise Chemical Technology Co.,Ltd
- Tel
- 15026594951
- rs@raise-chem.com
Bide Pharmatech Ltd.
- Tel
- 400-400-164-7117 18317119277
- product02@bidepharm.com
Shanghai AECOM Biotechnology Co. , Ltd.
- Tel
- 021-021-20956531 18116226605
- sui@neosunpharm.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com