Basic information Safety Supplier Related

OPIPRAMOL DIHYDROCHLORIDE

Basic information Safety Supplier Related

OPIPRAMOL DIHYDROCHLORIDE Basic information

Product Name:
OPIPRAMOL DIHYDROCHLORIDE
Synonyms:
  • 4-(3-(5h-dibenz(b,f)azepin-5-yl)propyl)-1-piperazineethanodihydrochloride
  • 4-(3-(5h-dibenzo(b,f)azepina-5-il)propil)-1-(2-idrossietil)piperazinadiclori
  • 5-(gamma-(beta-hydroxyethylpiperazino)propyl)-5h-dibenzo(b,f)azepinedihydroc
  • ensidon
  • insidondihydrochloride
  • opipramolhydrochloride
  • 4-[3-(5H-dibenz(b,f)azepin-5-yl)propyl]piperazine-1-ethanol dihydrochloride
  • Opipramol dihydrochloride >=98% (HPLC), solid
CAS:
909-39-7
MF:
C23H31Cl2N3O
MW:
436.41774
EINECS:
213-000-2
Product Categories:
  • Dopamine receptor
Mol File:
909-39-7.mol
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OPIPRAMOL DIHYDROCHLORIDE Chemical Properties

Melting point:
210° (FR M209); mp 228-230° (DE 1133729)
solubility 
H2O: ~24 mg/mL
form 
solid
color 
yellow
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Safety Information

Hazard Codes 
Xn,N
Risk Statements 
22-50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
TL9100000
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OPIPRAMOL DIHYDROCHLORIDE Usage And Synthesis

Originator

Insidon,Geigy,W. Germany,1962

Uses

antidepressant, antipsychotic;'sigma antagonist

Manufacturing Process

A solution of 5-(3-toluene-p-sulfonyloxypropyl)dibenzazepine (9.2g) and 1-(2hydroxyethyl)piperazine (8.6g) in anhydrous toluene (50 cc) is heated at boiling point under reflux for 4 hours.
After cooling, distilled water (75 cc) is added. The aqueous phase is decanted. The toluene solution is washed with distilled water (25 cc) and then extracted with N hydrohloric acid (40 cc). The hydrochloric acid solution is made alkaline to phenolphthalein with sodium hydroxide (d = 1.33).The base which separates is extracted with chloroform (50 cc). The chloroform solution is dried over anhydrous sodium sulfate and then evaporated to dryness. There are obtained 5-[3-(4-β-hydroxyethylpiperazino)propyl]dibenzazepine (7.95g), the dihydrochloride of which, crystallized from ethanol, melts at about 210°C.

Therapeutic Function

Antidepressant, Antipsychotic

OPIPRAMOL DIHYDROCHLORIDESupplier

Shanghai TaoSu Biochemical Technology Co., Ltd.
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