OPIPRAMOL DIHYDROCHLORIDE
OPIPRAMOL DIHYDROCHLORIDE Basic information
- Product Name:
- OPIPRAMOL DIHYDROCHLORIDE
- Synonyms:
-
- 4-(3-(5h-dibenz(b,f)azepin-5-yl)propyl)-1-piperazineethanodihydrochloride
- 4-(3-(5h-dibenzo(b,f)azepina-5-il)propil)-1-(2-idrossietil)piperazinadiclori
- 5-(gamma-(beta-hydroxyethylpiperazino)propyl)-5h-dibenzo(b,f)azepinedihydroc
- ensidon
- insidondihydrochloride
- opipramolhydrochloride
- 4-[3-(5H-dibenz(b,f)azepin-5-yl)propyl]piperazine-1-ethanol dihydrochloride
- Opipramol dihydrochloride >=98% (HPLC), solid
- CAS:
- 909-39-7
- MF:
- C23H31Cl2N3O
- MW:
- 436.41774
- EINECS:
- 213-000-2
- Product Categories:
-
- Dopamine receptor
- Mol File:
- 909-39-7.mol
OPIPRAMOL DIHYDROCHLORIDE Chemical Properties
- Melting point:
- 210° (FR M209); mp 228-230° (DE 1133729)
- solubility
- H2O: ~24 mg/mL
- form
- solid
- color
- yellow
OPIPRAMOL DIHYDROCHLORIDE Usage And Synthesis
Originator
Insidon,Geigy,W. Germany,1962
Uses
antidepressant, antipsychotic;'sigma antagonist
Manufacturing Process
A solution of 5-(3-toluene-p-sulfonyloxypropyl)dibenzazepine (9.2g) and 1-(2hydroxyethyl)piperazine (8.6g) in anhydrous toluene (50 cc) is heated at boiling point under reflux for 4 hours.
After cooling, distilled water (75 cc) is added. The aqueous phase is decanted. The toluene solution is washed with distilled water (25 cc) and then extracted with N hydrohloric acid (40 cc). The hydrochloric acid solution is made alkaline to phenolphthalein with sodium hydroxide (d = 1.33).The base which separates is extracted with chloroform (50 cc). The chloroform solution is dried over anhydrous sodium sulfate and then evaporated to dryness. There are obtained 5-[3-(4-β-hydroxyethylpiperazino)propyl]dibenzazepine (7.95g), the dihydrochloride of which, crystallized from ethanol, melts at about 210°C.
Therapeutic Function
Antidepressant, Antipsychotic
OPIPRAMOL DIHYDROCHLORIDESupplier
- Tel
- 021-33632979
- info@tsbiochem.com
- Tel
- 1-516-6625404
- support@alfa-chemistry.com
- Tel
- 571-89925085
- sales@amadischem.com
- Tel
- 029-87576359 17691182729
- 1018@dideu.com
- Tel
- +1-5166625404
- Info@alfa-chemistry.com