EURYCOMALACTONE(P) Chemical Properties

Melting point:

267～270℃

Boiling point:

588.1±50.0 °C(Predicted)

Density 

1.328±0.06 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

Soluble in DMSO

form 

Solid

pka

12.22±0.70(Predicted)

color 

White to off-white

EURYCOMALACTONE(P) Usage And Synthesis

Uses

Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC50 value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394)[1][2][3].

Definition

ChEBI: Eurycomalactone is a steroid lactone.

References

[1] Dukaew N, et, al. Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G?/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair. Oncol Res. 2020 Mar 27;28(2):161-175. DOI:10.3727/096504019X15736439848765
[2] Dukaew N, et, al. Inactivation of AKT/NF κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin. Oncol Rep. 2020 Oct;44(4):1441-1454. DOI:10.3892/or.2020.7710
[3] Malainer C, et, al. Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level. J Nat Prod. 2017 Dec 22;80(12):3186-3193. DOI:10.1021/acs.jnatprod.7b00503

EURYCOMALACTONE(P)(23062-24-0)Related Product Information

• 4-Hexanolide
• Polycaprolactone
• 13-alpha-(21)-Epoxyeurycomanone
• EURYCOMANONE
• 14,15-beta-dihydroxyklaineanone
• 8-OXOTRIDECANOIC ACID
• 2-Ketopelargonic acid ethyl ester
• (2-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER
• 4-Ketoundecanoicacid
• (-)-DIHYDROCRAVONE
• 3-HEPTYLDIHYDRO-5-METHYL-2(3H)-FURANONE
• (+)-DIHYDROCARVONE
• EURYCOMALACTONE(P)
• ETHYL 2-CYCLOHEXANONEACETATE