giredestrant Chemical Properties

Boiling point:

618.8±55.0 °C(Predicted)

Density 

1.333±0.06 g/cm3(Predicted)

pka

13.68±0.10(Predicted)

form 

Solid

color 

Light yellow to yellow

giredestrant Usage And Synthesis

Uses

Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity[1].

IC 50

ER

References

[1] C Metcalfe, et al. Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes

giredestrant(1953133-47-5)Related Product Information

• GDC-0623
• 2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-
• (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide
• GDC0575
• (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide
• 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
• GDC-0077
• (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one
• XL518
• DONEPEZIL HYDROCHLORIDE